Advances in understanding the pathogenesis of autoimmune disorders: focus on chemokines and lymphocyte trafficking
Date
2013
Authors
Comerford, I.
Kara, E.
McKenzie, D.
McColl, S.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
British Journal of Haematology, 2013; 164(3):329-341
Statement of Responsibility
Iain Comerford, Ervin E. Kara, Duncan R. McKenzie and Shaun R. McColl
Conference Name
Abstract
Lymphocyte trafficking is a key step in the pathogenesis of various autoimmune diseases. Recruitment of autoreactive lymphocytes to inflamed tissues is a defining feature of numerous persistent organ-specific autoimmune conditions and various therapies are now used in several of these diseases which appear to specifically block lymphocyte migration. Thus, better understanding of the molecular events involved in homing of autoreactive pathogenic lymphocytes may present novel opportunities for pharmacological intervention in autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, type-1 diabetes and psoriasis. This review describes recent progress in understanding lymphocyte trafficking in autoimmunity, focusing on the involvement of the chemokine and chemokine receptor superfamily. Possible strategies to improve therapeutics for autoimmune diseases arising from these studies are discussed.
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Dissertation Note
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Description
Link to a related website: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.12616, Open Access via Unpaywall
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© 2013 John Wiley & Sons Ltd.