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Development of a controlled release system for risperidone using polypyrrole: mechanistic studies

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dc.contributor.authorSvirskis, D.
dc.contributor.authorWright, B.
dc.contributor.authorTravas Sejdic, J.
dc.contributor.authorRodgers, A.
dc.contributor.authorGarg, S.
dc.date.issued2010
dc.description.abstractPolypyrrole (PPY) film has been selected as a platform material for drug delivery due to its inherent conductivity, ease of preparation and apparent biocompatibility. PPY films were prepared containing the antipsychotic drug risperidone as a model compound. Drug release profiles could be altered by applying different electrical stimulation to these films. Atomic force microscopy was used to investigate changes in PPY film thickness when different stimuli were applied. The highest levels of drug release were observed when PPY was reduced; this was accompanied by expansion of the film. Technology such as this could be utilized for implantable drug delivery devices, where the dose could be adjusted by external signaling.
dc.identifier.citationElectroanalysis, 2010; 22(4):439-444
dc.identifier.doi10.1002/elan.200900401
dc.identifier.issn1040-0397
dc.identifier.issn1521-4109
dc.identifier.orcidGarg, S. [0000-0001-7253-2629]
dc.identifier.urihttps://hdl.handle.net/1959.8/122761
dc.language.isoen
dc.publisherWiley-VCH Verlag GmbH
dc.rightsCopyright 2010 Wiley-VCH Verlag GmbH
dc.source.urihttps://doi.org/10.1002/elan.200900401
dc.subjectAtomic force microscopy
dc.subjectDrug delivery
dc.subjectP-toluene sulfonate
dc.subjectPolypyrrole
dc.subjectRisperidone
dc.subjectThin films
dc.titleDevelopment of a controlled release system for risperidone using polypyrrole: mechanistic studies
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9915910605801831

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