SimHap GUI: an intuitive graphical user interface for genetic association analysis

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dc.contributor.authorCarter, K.
dc.contributor.authorMcCaskie, P.
dc.contributor.authorPalmer, L.
dc.date.issued2008
dc.description.abstractBackground: Researchers wishing to conduct genetic association analysis involving single nucleotide polymorphisms (SNPs) or haplotypes are often confronted with the lack of user-friendly graphical analysis tools, requiring sophisticated statistical and informatics expertise to perform relatively straightforward tasks. Tools, such as the SimHap package for the R statistics language, provide the necessary statistical operations to conduct sophisticated genetic analysis, but lacks a graphical user interface that allows anyone but a professional statistician to effectively utilise the tool. Results: We have developed SimHap GUI, a cross-platform integrated graphical analysis tool for conducting epidemiological, single SNP and haplotype-based association analysis. SimHap GUI features a novel workflow interface that guides the user through each logical step of the analysis process, making it accessible to both novice and advanced users. This tool provides a seamless interface to the SimHap R package, while providing enhanced functionality such as sophisticated data checking, automated data conversion, and real-time estimations of haplotype simulation progress. Conclusion: SimHap GUI provides a novel, easy-to-use, cross-platform solution for conducting a range of genetic and non-genetic association analyses. This provides a free alternative to commercial statistics packages that is specifically designed for genetic association analysis.
dc.description.statementofresponsibilityKim W Carter, Pamela A McCaskie, Lyle J Palmer
dc.identifier.citationBMC Bioinformatics, 2008; 9(1):557-1-557-6
dc.identifier.doi10.1186/1471-2105-9-557
dc.identifier.issn1471-2105
dc.identifier.issn1471-2105
dc.identifier.orcidPalmer, L. [0000-0002-1628-3055]
dc.identifier.urihttp://hdl.handle.net/2440/86846
dc.language.isoen
dc.publisherBioMed Central
dc.relation.granthttp://purl.org/au-research/grants/arc/DP0663247
dc.rights© 2008 Carter et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.source.urihttps://doi.org/10.1186/1471-2105-9-557
dc.subjectHaplotypes
dc.subjectPolymorphism, Single Nucleotide
dc.subjectAlgorithms
dc.subjectComputer Graphics
dc.subjectSoftware
dc.subjectProgramming Languages
dc.subjectUser-Computer Interface
dc.subjectGenome-Wide Association Study
dc.titleSimHap GUI: an intuitive graphical user interface for genetic association analysis
dc.typeJournal article
pubs.publication-statusPublished

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