Comorbidity of chronic disease and potential treatment conflicts in older people dispensed antidepressants

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dc.contributor.authorCaughey, G.
dc.contributor.authorRoughead, E.
dc.contributor.authorShakib, S.
dc.contributor.authorMcDermott, R.
dc.contributor.authorVitry, A.
dc.contributor.authorGilbert, A.
dc.contributor.departmentClinical and Experimental Pharmacology
dc.date.issued2010
dc.description.abstractObjectives: the study aimed to examine the prevalence of comorbidity, the prescribing of potentially inappropriate medications and treatment conflicts in a large sample of older people who have been dispensed an antidepressant medicine. Methods: a cross-sectional study of administrative claims data from the Department of Veterans’ Affairs, Australia, 1 April–31 July 2007, of veterans aged ≥65 years was conducted. Comorbidities determined using the pharmaceutical-based comorbidity index, Rx-Risk-V. Concomitant medicines that may be potentially inappropriate for patients with depression and areas of treatment conflicts were determined from Australian clinical guidelines or reference compendia. Results: a total of 39,695 subjects were included, with a median of 5 comorbid conditions (inter-quartile range 3–6). Ninety percent of medicine use was attributed to the treatment of comorbid conditions. Eighty-seven percent of the study cohort was identified as having at least one comorbid condition that may cause a potential treatment conflict when an antidepressant is used. Those conditions of most concern included cardiovascular diseases, anxiety disorders, arthritis or pain management and osteoporosis. Conclusion: we observed a high level of potentially inappropriate prescribing and treatment conflicts that may arise when caring for older patients dispensed an antidepressant with comorbidity. These have the potential to place a large number of older people with depression at increased risk for adverse events.
dc.description.statementofresponsibilityGillian Elizabeth Caughey, Elizabeth Ellen Roughead, Sepehr Shakib, Robyn A. McDermott, Agnes I. Vitry and Andrew L. Gilbert
dc.identifier.citationAge and Ageing, 2010; 39(4):488-494
dc.identifier.doi10.1093/ageing/afq055
dc.identifier.issn0002-0729
dc.identifier.issn1468-2834
dc.identifier.orcidCaughey, G. [0000-0003-1192-4121]
dc.identifier.orcidShakib, S. [0000-0002-7199-5733]
dc.identifier.urihttp://hdl.handle.net/2440/62822
dc.language.isoen
dc.publisherOxford Univ Press
dc.rights© The Author 2010. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved.
dc.source.urihttps://doi.org/10.1093/ageing/afq055
dc.subjectcomorbidity
dc.subjectantidepressant
dc.subjectdepression
dc.subjectchronic disease
dc.subjectelderly
dc.titleComorbidity of chronic disease and potential treatment conflicts in older people dispensed antidepressants
dc.typeJournal article
pubs.publication-statusPublished

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