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COX-2 inhibition and thrombotic tendency: a need for surveillance

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dc.contributor.authorCleland, L.
dc.contributor.authorJames, M.
dc.contributor.authorStamp, L.
dc.contributor.authorPenglis, P.
dc.date.issued2001
dc.description.abstractCyclooxygenase-2 (COX-2) inhibitors belong to a new class of drugs which have anti-inflammatory efficacy similar to that of traditional non-steroidal anti-inflammatory drugs (NSAIDs), but are associated with a reduced incidence of adverse upper gastrointestinal events. Biochemical evidence that COX-2 inhibitors could promote or exacerbate a tendency to thrombosis is supported by recent results from clinical trials and case reports. Two agents in this class, celecoxib and rofecoxib, have been listed on the Pharmaceutical Benefits Scheme (PBS) for very broad indications in chronic arthropathies, suggesting that they will move into widespread community use. It is important to canvass the possibility that use of these agents could be associated with thrombotic events.
dc.description.statementofresponsibilityCleland, L G ; James, M J ; Stamp, L K ; Penglis, P S
dc.identifier.citationMedical Journal of Australia, 2001; 175(20 August 2001):214-217
dc.identifier.doi10.5694/j.1326-5377.2001.tb143099.x
dc.identifier.issn0025-729X
dc.identifier.issn1326-5377
dc.identifier.orcidJames, M. [0000-0002-4918-2998]
dc.identifier.urihttp://hdl.handle.net/2440/9686
dc.language.isoen
dc.publisherAustralasian Med Publ Co Ltd
dc.source.urihttps://doi.org/10.5694/j.1326-5377.2001.tb143099.x
dc.subjectHumans
dc.subjectArthritis, Rheumatoid
dc.subjectGastrointestinal Diseases
dc.subjectVenous Thrombosis
dc.subjectSulfonamides
dc.subjectAspirin
dc.subjectLactones
dc.subjectSulfones
dc.subjectPyrazoles
dc.subjectAnti-Inflammatory Agents, Non-Steroidal
dc.subjectCyclooxygenase Inhibitors
dc.subjectRisk Factors
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectRandomized Controlled Trials as Topic
dc.subjectCelecoxib
dc.titleCOX-2 inhibition and thrombotic tendency: a need for surveillance
dc.typeJournal article
pubs.publication-statusPublished

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