One immune system plays many parts: The dynamic role of the immune system in chronic pain and opioid pharmacology.

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dc.contributor.authorMustafa, S.
dc.contributor.authorBajic, J.E.
dc.contributor.authorBarry, B.
dc.contributor.authorEvans, S.
dc.contributor.authorSiemens, K.R.
dc.contributor.authorHutchinson, M.R.
dc.contributor.authorGrace, P.M.
dc.date.issued2023
dc.description.abstractThe transition from acute to chronic pain is an ongoing major problem for individuals, society and healthcare systems around the world. It is clear chronic pain is a complex multidimensional biological challenge plagued with difficulties in pain management, specifically opioid use. In recent years the role of the immune system in chronic pain and opioid pharmacology has come to the forefront. As a highly dynamic and versatile network of cells, tissues and organs, the immune system is perfectly positioned at the microscale level to alter nociception and drive structural adaptations that underpin chronic pain and opioid use. In this review, we highlight the need to understand the dynamic and adaptable characteristics of the immune system and their role in the transition, maintenance and resolution of chronic pain. The complex multidimensional interplay of the immune system with multiple physiological systems may provide new transformative insight for novel targets for clinical management and treatment of chronic pain.
dc.description.statementofresponsibilitySanam Mustafa, Juliana E. Bajic, Benjamin Barry, Samuel Evans, Kariel R. Siemens, Mark R. Hutchinson, Peter M. Grace
dc.identifier.citationNeuropharmacology, 2023; 228:1-14
dc.identifier.doi10.1016/j.neuropharm.2023.109459
dc.identifier.issn0028-3908
dc.identifier.issn1873-7064
dc.identifier.orcidMustafa, S. [0000-0002-8677-5151]
dc.identifier.orcidBajic, J.E. [0000-0002-2019-088X]
dc.identifier.orcidBarry, B. [0000-0003-4604-7210]
dc.identifier.orcidSiemens, K.R. [0000-0003-4371-708X]
dc.identifier.orcidHutchinson, M.R. [0000-0003-2154-5950]
dc.identifier.urihttps://hdl.handle.net/2440/138170
dc.language.isoen
dc.publisherElsevier BV
dc.relation.granthttp://purl.org/au-research/grants/arc/FT180100565
dc.rights© 2023 Elsevier Ltd. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.neuropharm.2023.109459
dc.subjectA20
dc.subjectChronic pain
dc.subjectFcγ receptors (FcγRs)
dc.subjectNeuroimmune interactions
dc.subjectToll-like receptors
dc.subject.meshHumans
dc.subject.meshAnalgesics, Opioid
dc.subject.meshChronic Pain
dc.subject.meshOpioid-Related Disorders
dc.subject.meshPain Management
dc.subject.meshImmune System
dc.titleOne immune system plays many parts: The dynamic role of the immune system in chronic pain and opioid pharmacology.
dc.typeJournal article
pubs.publication-statusPublished

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