A Preliminary Study on the Postoperative Survival of Patients Given Aspirin After Resection for Squamous Cell Carcinoma of the Esophagus or Adenocarcinoma of the Cardia

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dc.contributor.authorLiu, J.
dc.contributor.authorJamieson, G.
dc.contributor.authorWu, T.
dc.contributor.authorZhu, G.
dc.contributor.authorDrew, P.
dc.date.issued2009
dc.descriptionThe original publication can be found at www.springerlink.com
dc.description.abstractBackground We examined the effect of aspirin on survival following resection for squamous cell carcinoma (SCC) of the esophagus or adenocarcinoma of the gastric cardia. Methods Patients who underwent esophagectomy for these cancers between May 2000 and December 2002 were allocated to one of three groups and given daily either a low dose of aspirin, placebo, or no tablets. Results The 5-year survival for all patients on aspirin (445) was 51.2%, placebo (658) 41%, and no tablet (495) 42.3% (P = 0.04 for difference between treatments). The 5-year survival for all SCC patients on aspirin (267) was 49.8%, placebo (433) 42.2%, and no tablet (343) 41.2% (P = 0.26). There was a significant improvement in survival for patients with adenocarcinoma of the cardia on aspirin compared with the two control groups combined (P = 0.029). Survival for T2N0M0 SCC patients was significantly improved with aspirin (71) compared with placebo (167) or no tablet (134) (P = 0.0004). However, there was no significant difference between the survival curves for T2N0M0 adenocarcinoma patients on aspirin (21) and the two control groups combined (65) (P = 0.29). Conclusions The results of this preliminary study support further investigation of aspirin as adjuvant therapy to improve survival in subsets of postesophagectomy patients.
dc.description.statementofresponsibilityJun-Feng Liu, Glyn G. Jamieson, Tie-Cheng Wu, Gui-Jun Zhu and Paul A. Drew
dc.identifier.citationAnnals of Surgical Oncology, 2009; 16(5):1397-1402
dc.identifier.doi10.1245/s10434-009-0382-z
dc.identifier.issn1068-9265
dc.identifier.issn1534-4681
dc.identifier.orcidDrew, P. [0000-0001-5661-4771]
dc.identifier.urihttp://hdl.handle.net/2440/51593
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.source.urihttps://doi.org/10.1245/s10434-009-0382-z
dc.subjectCardia
dc.subjectHumans
dc.subjectAdenocarcinoma
dc.subjectCarcinoma, Squamous Cell
dc.subjectEsophageal Neoplasms
dc.subjectStomach Neoplasms
dc.subjectCisplatin
dc.subjectAspirin
dc.subjectFluorouracil
dc.subjectEtoposide
dc.subjectAntineoplastic Combined Chemotherapy Protocols
dc.subjectCombined Modality Therapy
dc.subjectChemotherapy, Adjuvant
dc.subjectRadiotherapy, Adjuvant
dc.subjectEsophagectomy
dc.subjectGastrectomy
dc.subjectSurvival Analysis
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectCyclooxygenase 2 Inhibitors
dc.titleA Preliminary Study on the Postoperative Survival of Patients Given Aspirin After Resection for Squamous Cell Carcinoma of the Esophagus or Adenocarcinoma of the Cardia
dc.typeJournal article
pubs.publication-statusPublished

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