Sudden death and the forensic evaluation of neurocutaneous syndromes

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dc.contributor.authorJensen, L.
dc.contributor.authorHeath, K.
dc.contributor.authorScott, G.
dc.contributor.authorByard, R.
dc.date.issued2009
dc.description.abstractOn occasion the forensic evaluation of individuals who have died suddenly and unexpectedly may reveal intracranial vascular abnormalities such as capillary, venous- and arteriovenous malformations. Such vascular abnormalities may form part of a heterogeneous group of disorders called neurocutaneous syndromes and involve the skin, nervous system and other organ systems. These unusual conditions include Sturge–Weber, Osler–Weber–Rendu, Klippel–Trenaunay, Von Hippel-Lindau, Proteus and Wyburn-Mason syndromes in addition to ataxia telangiectasia. Causes and mechanisms of unexpected death include epileptic seizures, intracranial haemorrhage and thromboses. Differentiating these conditions at autopsy is important because of variable inheritance patterns and occasionally inaccurate clinical classifications. The autopsy evaluation requires review of the medical and family histories, and full external and internal examinations with photographic documentation and histologic sampling of lesions. Formal neuropathology, storage of blood and tissues for molecular studies if required, and liaison with a medical geneticist should be considered
dc.description.statementofresponsibilityLisbeth Jensen, Karen J. Heath, Grace Scott and Roger W. Byard
dc.description.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/711392/description#description
dc.identifier.citationJournal of Clinical Forensic and Legal Medicine: an international journal of forensic and legal medicine, 2009; 16(7):369-374
dc.identifier.doi10.1016/j.jflm.2009.04.004
dc.identifier.issn1752-928X
dc.identifier.issn1532-2009
dc.identifier.orcidByard, R. [0000-0002-0524-5942]
dc.identifier.urihttp://hdl.handle.net/2440/51151
dc.language.isoen
dc.publisherChurchill Livingstone
dc.rightsCopyright © 2009 Elsevier Ltd and Faculty of Forensic and Legal Medicine Published by Elsevier B.V.
dc.source.urihttps://doi.org/10.1016/j.jflm.2009.04.004
dc.subjectNeurocutaneous syndromes
dc.subjectSudden death
dc.subjectSturge–Weber
dc.subjectOsler–Weber–Rendu
dc.subjectKlippel–Trenaunay–Weber
dc.titleSudden death and the forensic evaluation of neurocutaneous syndromes
dc.typeJournal article
pubs.publication-statusPublished

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