The effect of depressive symptoms on disability-free survival in healthy older adults: a prospective cohort study

Simple item page
dc.contributor.authorRoebuck, G.
dc.contributor.authorLotfaliany, M.
dc.contributor.authorAgustini, B.
dc.contributor.authorForbes, M.
dc.contributor.authorMohebbi, M.
dc.contributor.authorMcNeil, J.
dc.contributor.authorWoods, R.L.
dc.contributor.authorReid, C.M.
dc.contributor.authorNelson, M.R.
dc.contributor.authorShah, R.C.
dc.contributor.authorRyan, J.
dc.contributor.authorNewman, A.B.
dc.contributor.authorOwen, A.
dc.contributor.authorFreak-Poli, R.
dc.contributor.authorStocks, N.
dc.contributor.authorBerk, M.
dc.contributor.authorASPREE Investigator Group,
dc.date.issued2022
dc.descriptionPublished online January 2023
dc.description.abstractBackground: Gerontology and ageing research are increasingly focussing on healthy life span (healthspan), the period of life lived free of serious disease and disability. Late-life depression (LLD) is believed to impact adversely on physical health. However, no studies have examined its effect on healthspan. This study investigated the effect of LLD and subthreshold depression on disability-free survival, a widely accepted measure of healthspan. Methods: This prospective cohort study used data from the ASPirin in Reducing Events in the Elderly study. Participants were aged ≥70 years (or ≥65 years for African-American and Hispanic participants) and free of dementia, physical disability and cardiovascular disease. Depressive symptoms were measured using the 10-item Centre for Epidemiological Studies Depression Scale (CES-D-10). LLD and subthreshold depression were defined as CES-D-10 scores ≥8 and 3–7, respectively. Disability-free survival was defined as survival free of dementia and persistent physical disability. Results: A total of 19,110 participants were followed up for a maximum of 7.3 years. In female participants, LLD was associated with lower disability-free survival adjusting for sociodemographic and lifestyle factors, medical comorbidities, polypharmacy, physical function and antidepressant use (HR, 1.50; 95% CI, 1.23–1.82). In male participants, LLD was associated with lower disability-free survival adjusting for sociodemographic and lifestyle factors (HR, 1.30; 95% CI, 1.03–1.64). Subthreshold depression was also associated with lower disability-free survival in both sexes. Conclusions: LLD may be a common and important risk factor for shortened healthspan.
dc.description.statementofresponsibilityGreg Roebuck, Mojtaba Lotfaliany, Bruno Agustini, Malcolm Forbes, Mohammadreza Mohebbi, John McNeil, Robyn L. Woods, Christopher M. Reid, Mark R. Nelson, Raj C. Shah, Joanne Ryan, Anne B. Newman, Alice Owen, Rosanne Freak-Poli, Nigel Stocks, Michael Berk, ASPREE Investigator Group
dc.identifier.citationActa Psychiatrica Scandinavica, 2022; 147(1):92-104
dc.identifier.doi10.1111/acps.13513
dc.identifier.issn0001-690X
dc.identifier.issn1600-0447
dc.identifier.orcidStocks, N. [0000-0002-9018-0361]
dc.identifier.urihttps://hdl.handle.net/2440/136937
dc.language.isoen
dc.publisherWiley
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1127060
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1081901
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/334047
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1173690
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1136372
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1135727
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1156072
dc.rights© 2022 The Authors. Acta Psychiatrica Scandinavica published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.source.urihttps://doi.org/10.1111/acps.13513
dc.subjectASPREE Investigator Group
dc.subjectageing; disability‐free survival; healthspan; late‐life depression; psychiatry
dc.titleThe effect of depressive symptoms on disability-free survival in healthy older adults: a prospective cohort study
dc.typeJournal article
pubs.publication-statusPublished

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
hdl_136937.pdf
Size:
1.39 MB
Format:
Adobe Portable Document Format
Description:
Published version
Download

Collections

General Practice publications