Endothelial progenitor cells enhance islet engraftment, influence β-cell function and modulate islet connexin 36 expression

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dc.contributor.authorPenko, D.
dc.contributor.authorRojas-Canales, D.
dc.contributor.authorMohanasundaram, D.
dc.contributor.authorPeiris, H.
dc.contributor.authorSun, W.
dc.contributor.authorDrogemuller, C.
dc.contributor.authorKeating, D.
dc.contributor.authorCoates, P.
dc.contributor.authorBonder, C.
dc.contributor.authorJessup, C.
dc.date.issued2015
dc.description.abstractThe success of pancreatic islet transplantation is limited by delayed engraftment and suboptimal function in the longer term. Endothelial progenitor cells (EPCs) represent a potential cellular therapy that may improve the engraftment of transplanted pancreatic islets. In addition, EPCs may directly affect the function of pancreatic β-cells. The objective of this study was to examine the ability of EPCs to enhance pancreatic islet transplantation in a murine syngeneic marginal mass transplant model and to examine the mechanisms through which this occurs. We found that cotransplanted EPCs improved the cure rate and initial glycemic control of transplanted islets. Gene expression data indicate that EPCs, or their soluble products, modulate the expression of the β-cell surface molecule connexin 36 and affect glucose-stimulated insulin release in vitro. In conclusion, EPCs are a promising candidate for improving outcomes in islet transplantation, and their mechanisms of action warrant further study.
dc.description.statementofresponsibilityDaniella Penko, Darling Rojas-Canales, Daisy Mohanasundaram, Heshan S. Peiris, Wai Y. Sun, Christopher J. Drogemuller, Damien J. Keating, P. Toby H. Coates, Claudine S. Bonder, and Claire F. Jessup
dc.identifier.citationCell Transplantation, 2015; 24(1):37-48
dc.identifier.doi10.3727/096368913X673423
dc.identifier.issn0963-6897
dc.identifier.issn1555-3892
dc.identifier.orcidDrogemuller, C. [0000-0001-9770-4845]
dc.identifier.orcidBonder, C. [0000-0001-9875-967X]
dc.identifier.orcidJessup, C. [0000-0003-1184-6653]
dc.identifier.urihttp://hdl.handle.net/2440/89661
dc.language.isoen
dc.publisherCognizant Communication Corporation
dc.rightsCopyright © 2015 Cognizant Comm. Corp.
dc.source.urihttps://doi.org/10.3727/096368913x673423
dc.subjectIslets of Langerhans; Islet transplantation; Diabetes; Endothelial progenitor cells (EPCs); Connexin 36; Cell therapy
dc.titleEndothelial progenitor cells enhance islet engraftment, influence β-cell function and modulate islet connexin 36 expression
dc.title.alternativeEndothelial progenitor cells enhance islet engraftment, influence beta-cell function and modulate islet connexin 36 expression
dc.typeJournal article
pubs.publication-statusPublished

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