Association between serum keptin concentrations and insulin resistance: A population-based study from China

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dc.contributor.authorZuo, H.
dc.contributor.authorShi, Z.
dc.contributor.authorYuan, B.
dc.contributor.authorDai, Y.
dc.contributor.authorWu, G.
dc.contributor.authorHussain, A.
dc.contributor.editorPereira, R.I.
dc.date.issued2013
dc.description.abstractBACKGROUND Insulin resistance contributes to the cardio-metabolic risk. The effect of leptin in obese and overweight population on insulin resistance was seldom reported. METHODS A total of 1234 subjects (572 men and 662 women) aged ≥18 y was sampled by the procedure. Adiposity measures included BMI, waist circumference, hip circumference, WHR, upper arm circumference, triceps skinfold and body fat percentage. Serum leptin concentrations were measured by an ELISA method. The homeostasis model (HOMA-IR) was applied to estimate insulin resistance. RESULTS In men, BMI was the variable which was most strongly correlated with leptin, whereas triceps skinfold was most sensitive for women. More importantly, serum leptin levels among insulin resistant subjects were almost double compared to the subjects who had normal insulin sensitivity at the same level of adiposity in both men and women, after controlling for potential confounders. In addition, HOMA-IR increased significantly across leptin quintiles after adjustment for age, BMI, total energy intake, physical activity and smoking status in both men and women (p for trend <0.0001). CONCLUSIONS There was a significant association between HOMA-IR and serum leptin concentrations in Chinese men and women, independently of adiposity levels. This may suggest that serum leptin concentration is an important predictor of insulin resistance and other metabolic risks irrespective of obesity levels. Furthermore, leptin levels may be used to identify the cardio-metabolic risk in obese and overweight population.
dc.description.statementofresponsibilityHui Zuo, Zumin Shi, Baojun Yuan, Yue Dai, Gaolin Wu, Akhtar Hussain
dc.identifier.citationPLoS One, 2013; 8(1):1-7
dc.identifier.doi10.1371/journal.pone.0054615
dc.identifier.issn1932-6203
dc.identifier.issn1932-6203
dc.identifier.orcidShi, Z. [0000-0002-3099-3299]
dc.identifier.urihttp://hdl.handle.net/2440/79350
dc.language.isoen
dc.publisherPublic Library of Science
dc.rights© 2013 Zuo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.source.urihttps://doi.org/10.1371/journal.pone.0054615
dc.subjectHumans
dc.subjectInsulin Resistance
dc.subjectObesity
dc.subjectLeptin
dc.subjectAnthropometry
dc.subjectBody Mass Index
dc.subjectGenetics, Population
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectChina
dc.subjectFemale
dc.subjectMale
dc.subjectOverweight
dc.subjectStatistics as Topic
dc.subjectGenetic Association Studies
dc.titleAssociation between serum keptin concentrations and insulin resistance: A population-based study from China
dc.typeJournal article
pubs.publication-statusPublished

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