Evaluation of combined live, attenuated respiratory syncytial virus and parainfluenza 3 virus vaccines in infants and young children

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dc.contributor.authorBelshe, R.
dc.contributor.authorNewman, F.
dc.contributor.authorAnderson, E.
dc.contributor.authorWright, P.
dc.contributor.authorKarron, R.
dc.contributor.authorTollefson, S.
dc.contributor.authorHenderson, F.
dc.contributor.authorMeissner, H.
dc.contributor.authorMadhi, S.
dc.contributor.authorRoberton, D.
dc.contributor.authorMarshall, H.
dc.contributor.authorLoh, R.
dc.contributor.authorSly, P.
dc.contributor.authorMurphy, B.
dc.contributor.authorTatem, J.
dc.contributor.authorRandolph, V.
dc.contributor.authorHackell, J.
dc.contributor.authorGruber, W.
dc.contributor.authorTsai, T.
dc.date.issued2004
dc.description© 2004 by the Infectious Diseases Society of America. All rights reserved.
dc.description.abstractWe evaluated a combination respiratory syncytial virus (RSV) and parainfluenza 3 virus (PIV3) live, attenuated intranasal vaccine for safety, viral replication, and immunogenicity in doubly seronegative children 6–18 months old. RSV cpts-248/404 and PIV3-cp45 vaccines were combined in a dose of 105 plaque-forming units of each per 0.5-mL dose and compared with monovalent vaccines or placebo. The virus shedding pattern of RSV was not different between monovalent RSV cpts-248/404 vaccine and combination vaccine. Modest reductions in the shedding of PIV3-cp45 vaccine virus were found after the administration of RSV cpts-248/404 and PIV3-cp45 vaccine, relative to monovalent PIV3 vaccine; 16 (76%) of 21 children given combination vaccine shed PIV3-cp45 versus 11 (92%) of 12 of those given monovalent PIV3 vaccine. Both vaccines were immunogenic, and antibody responses were similar between the monovalent groups and the combination group. Combined RSV/PV3 vaccine is feasible for simultaneous administration, and further studies are warranted.
dc.description.statementofresponsibilityRobert B. Belshe, Frances K. Newman, Edwin L. Anderson, Peter F. Wright, Ruth A. Karron,Sharon Tollefson, Frederick W. Henderson, H. Cody Meissner, Shabir Madhi, Don Roberton, Helen Marshall,Richard Loh, Peter Sly, Brian Murphy, Joanne M. Tatem, Valerie Randolph, Jill Hackell, William Gruber and Theodore F. Tsai
dc.identifier.citationJournal of Infectious Diseases, 2004; 190(12):2096-2103
dc.identifier.doi10.1086/425981
dc.identifier.issn0022-1899
dc.identifier.issn1537-6613
dc.identifier.orcidMarshall, H. [0000-0003-2521-5166]
dc.identifier.urihttp://hdl.handle.net/2440/7511
dc.language.isoen
dc.publisherUniv Chicago Press
dc.source.urihttps://doi.org/10.1086/425981
dc.subjectHumans
dc.subjectParainfluenza Virus 3, Human
dc.subjectRespirovirus Infections
dc.subjectRespiratory Syncytial Virus Infections
dc.subjectVaccines, Combined
dc.subjectParainfluenza Vaccines
dc.subjectRespiratory Syncytial Virus Vaccines
dc.subjectAntibodies, Viral
dc.subjectAdministration, Intranasal
dc.subjectDouble-Blind Method
dc.subjectVirus Shedding
dc.subjectInfant
dc.titleEvaluation of combined live, attenuated respiratory syncytial virus and parainfluenza 3 virus vaccines in infants and young children
dc.typeJournal article
pubs.publication-statusPublished

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