Nano engineered surfaces to control biological response /
Files
(Published version)
Date
2019
Authors
Madathiparambil Visalakshan, Rahul
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
thesis
Citation
Statement of Responsibility
Conference Name
Abstract
To overcome the risks and challenges associated with biomaterial implantation and foreign body response, gaining a mechanistic understanding of protein/cell/biomaterial interface interactions is crucial. The aim of this thesis was to investigate serum protein adsorption patterns and protein structural changes upon adsorption to surfaces with tailored surface chemistry and well-defined nanotopography surfaces, to establish a link between biomaterial surface properties and ensuing immune cell reactions. This study demonstrated distinct protein unfolding patterns with nanotopography surfaces, which influenced the expression of proinflammatory cytokines and Mac-1 positive THP-1 monocytes cells attachment. The effect of hydrophobicity in the selectivity of serum protein adsorption and immune response was also studied on a range of different surface chemistry surfaces.
School/Discipline
University of South Australia. School of Engineering.
Future Industries Institute
Future Industries Institute
Dissertation Note
Thesis (PhD(Biomaterials Engineering and Nanomedicine))--University of South Australia, 2019.
Provenance
Copyright 2019 Rahul Madathiparambil Visalakshan.
Description
1 ethesis (xxii, 218 pages) :
illustrations (chiefly colour), colour charts.
Includes bibliographical references (pages 199-218)
illustrations (chiefly colour), colour charts.
Includes bibliographical references (pages 199-218)
Access Status
506 0#$fstar $2Unrestricted online access