Bioenergetic-based neuroprotection and glaucoma

Simple item page
dc.contributor.authorSchober, M.
dc.contributor.authorChidlow, G.
dc.contributor.authorWood, J.
dc.contributor.authorCasson, R.
dc.date.issued2008
dc.descriptionWebsite © 2008 Ingenta. Article copyright remains with the publisher, society or author(s) as specified within the article
dc.description.abstractPrimary open-angle glaucoma (POAG) is a pressure-sensitive optic neuropathy which results in the death of retinal ganglion cells and causes associated loss of vision. Presently, the only accepted treatment strategy is to lower the intraocular pressure; however, for some patients this is insufficient to prevent progressive disease. Although the pathogenesis of POAG remains unclear, there is considerable evidence that energy failure at the optic nerve head may be involved. Neuroprotection, a strategy which directly enhances the survival of neurons, is desirable, but remains clinically elusive. One particular form of neuroprotection involves the notion of enhancing the energy supply of neurons. These `bioenergetic' methods of neuroprotection have proven successful in animal models of other neurodegenerative diseases and conditions, including Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and traumatic brain injury, but have been relatively unexplored in glaucoma models. This review focuses on some of the potential approaches for bioenergetic neuroprotection in the retina, including increasing the energy buffering capacity of damaged cells, decreasing the permeability of the mitochondrial membrane pore and free radical scavenging.
dc.description.statementofresponsibilitySchober Michael S, Chidlow Glyn, Wood John PM and Casson Robert J
dc.identifier.citationClinical and Experimental Ophthalmology, 2008; 36(4):377-385
dc.identifier.doi10.1111/j.1442-9071.2008.01740.x
dc.identifier.issn1442-6404
dc.identifier.issn1442-9071
dc.identifier.orcidChidlow, G. [0000-0001-7371-0239]
dc.identifier.orcidCasson, R. [0000-0003-2822-4076]
dc.identifier.urihttp://hdl.handle.net/2440/53719
dc.language.isoen
dc.publisherBlackwell Publishing Asia
dc.source.urihttps://doi.org/10.1111/j.1442-9071.2008.01740.x
dc.subjectbioenergetic neuroprotection
dc.subjectexcitotoxicity
dc.subjectglaucoma
dc.titleBioenergetic-based neuroprotection and glaucoma
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Opthalmology & Visual Sciences publications