Development and evaluation of ovine polyclonal antibody therapies for the treatment of severe influenza infection and bacterial sepsis /
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(Published version)
Date
2016
Authors
Stevens, Natalie Emilia,
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thesis
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Abstract
Severe infections and their complications are growing health burdens in Australian society, with an increasing number of elderly, chronically ill and immunosuppressed people at high risk of contracting infections requiring costly critical care supports. While preventative measures for severe infections are undoubtedly important, there remains a need for additional therapies for such diseases where patients are dependent on supportive care. Passive immunotherapies utilising polyclonal antibodies (pAbs) are suitable platforms for the development of critical care therapies; they have a good safety profile and the broad reactive capacity of pAbs enable simultaneous targeting of multiple pathways. The application of ovine pAbs to the clinical scenarios of severe influenza infection and bacterial sepsis were explored herein.
School/Discipline
University of South Australia. School of Pharmacy and Medical Sciences.
School of Pharmacy and Medical Sciences.
School of Pharmacy and Medical Sciences.
Dissertation Note
Thesis (PhD(Medical Science))--University of South Australia, 2016.
Provenance
Copyright 2016 Natalie Stevens
Description
1 ethesis (xvi, 210 pages) :
colour illustrations
Includes bibliographical references (pages 187-210)
colour illustrations
Includes bibliographical references (pages 187-210)
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506 0#$fstar $2Unrestricted online access