The renin-angiotensin system and nociception in the spontaneously hypertensive rat

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dc.contributor.authorIrvine, R.
dc.contributor.authorWhite, J.
dc.contributor.authorHead, R.
dc.date.issued1995
dc.description.abstractThis study investigated the effects of captopril, hydralazine and losartan on the locomotor activity, tailflick and hot plate latencies in spontaneously hypertensive rats (SHR) and their genetic controls the Wistar-Kyoto rat (WKY). The increased hot plate latencies normally exhibited by the spontaneously hypertensive rat were reduced or abolished by captopril ( 95 mg/kg/day p.o.) and losartan (18 mg/kg/day p.o.) treatment, but were unaffected by hydralazine (19 mg/kg/day p.o.). There were no observable effects of any of the drugs on tailflick latencies or locomotor activity. The results highlight a potential role for angiotensin II in analgesia that is independent of blood pressure change.
dc.description.statementofresponsibilityRodney J Irvine, Jason M White and Richard J Head
dc.identifier.citationLife Sciences, 1995; 56(13):1073-1078
dc.identifier.doi10.1016/0024-3205(95)00043-6
dc.identifier.issn0024-3205
dc.identifier.issn1879-0631
dc.identifier.orcidHead, R. [0000-0002-1196-0926]
dc.identifier.urihttp://hdl.handle.net/2440/14498
dc.language.isoen
dc.publisherPergamon Press
dc.rightsCopyright © 1995 Elsevier Science Ltd
dc.source.urihttps://doi.org/10.1016/0024-3205(95)00043-6
dc.subjectspontaneously hypertensive rat
dc.subjectanalgesia
dc.subjectcaptopril
dc.subjectlosartan
dc.titleThe renin-angiotensin system and nociception in the spontaneously hypertensive rat
dc.typeJournal article
pubs.publication-statusPublished

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