Porous ultrathin-shell microcapsules designed by microfluidics for selective permeation and stimuli-triggered release

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dc.contributor.authorChen, L.
dc.contributor.authorXiao, Y.
dc.contributor.authorZhang, Z.
dc.contributor.authorZhao, C.X.
dc.contributor.authorGuo, B.
dc.contributor.authorYe, F.
dc.contributor.authorChen, D.
dc.date.issued2022
dc.descriptionPublished 5 November 2022
dc.description.abstractMicrocapsules are versatile delivery vehicles and widely used in various areas. Generally, microcapsules with solid shells lack selective permeation and only exhibit a simple release mode. Here, we use ultrathin-shell waterin-oil-in-water double emulsions as templates and design porous ultrathin-shell microcapsules for selective permeation and multiple stimuli-triggered release. After preparation of double emulsions by microfluidic devices, negatively charged shellac nanoparticles dispersed in the inner water core electrostatically complex with positively charged telechelic α,ω-diamino functionalized polydimethylsiloxane polymers dissolved in the middle oil shell at the water/oil interface, thus forming a porous shell of shellac nanoparticles cross-linked by telechelic polymers. Subsequently, the double emulsions become porous microcapsules upon evaporation of the middle oil phase. The porous ultrathin-shell microcapsules exhibit excellent properties, including tunable size, selective permeation and stimuli-triggered release. Small molecules or particles can diffuse across the shell, while large molecules or particles are encapsulated in the core, and release of the encapsulated cargos can be triggered by osmotic shock or a pH change. Due to their unique performance, porous ultrathin-shell microcapsules present promising platforms for various applications, such as drug delivery.
dc.description.statementofresponsibilityLi Chen, Yao Xiao, Zhiming Zhang, Chun-Xia Zhao, Baoling Guo, Fangfu Ye, Dong Chen
dc.identifier.citationFrontiers of Chemical Science and Engineering, 2022; 16(11):1643-1650
dc.identifier.doi10.1007/s11705-022-2201-z
dc.identifier.issn2095-0179
dc.identifier.issn2095-0187
dc.identifier.urihttps://hdl.handle.net/2440/136991
dc.language.isoen
dc.publisherSpringer Nature
dc.relation.granthttp://purl.org/au-research/grants/arc/DP200101238
dc.relation.granthttp://purl.org/au-research/grants/arc/DP210103079
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/2008698
dc.rights© Higher Education Press 2022
dc.source.urihttps://doi.org/10.1007/s11705-022-2201-z
dc.subjectmicrocapsule; emulsion; microfluidics; selective permeation; stimuli-triggered release
dc.titlePorous ultrathin-shell microcapsules designed by microfluidics for selective permeation and stimuli-triggered release
dc.typeJournal article
pubs.publication-statusPublished

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