Visual field loss associated with vigabatrin: pathological correlations

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dc.contributor.authorRavindran, J.
dc.contributor.authorBlumbergs, P.
dc.contributor.authorCrompton, J.
dc.contributor.authorPietris, G.
dc.contributor.authorWaddy, H.
dc.date.issued2001
dc.description© 2001 by Journal of Neurology, Neurosurgery, and Psychiatry
dc.description.abstractPathological changes are reported in the anterior visual pathways of a 41 year old man with complex partial seizures treated with vigabatrin who developed bilateral visual field constriction. There was peripheral retinal atrophy with loss of ganglion cells and loss of nerve fibres in the optic nerves, chiasm, and tracts. No evidence of intramyelinic oedema was seen. These findings suggest that the primary site of injury lies within the ganglion cells in the retina. The degree of atrophy seen would suggest that the visual field loss is irreversible.
dc.identifier.citationJournal of Neurology, Neurosurgery and Psychiatry, 2001; 70(6):787-789
dc.identifier.doi10.1136/jnnp.70.6.787
dc.identifier.issn0022-3050
dc.identifier.issn1468-330X
dc.identifier.urihttp://hdl.handle.net/2440/32702
dc.language.isoen
dc.publisherBritish Med Journal Publ Group
dc.source.urihttp://jnnp.bmj.com/cgi/content/abstract/70/6/787
dc.subjectVisual Pathways
dc.subjectRetina
dc.subjectHumans
dc.subjectEpilepsy, Complex Partial
dc.subjectVigabatrin
dc.subjectAnticonvulsants
dc.subjectVisual Fields
dc.subjectAdult
dc.subjectMale
dc.titleVisual field loss associated with vigabatrin: pathological correlations
dc.typeJournal article
pubs.publication-statusPublished

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