TNF-receptor levels in preeclampsia - results of a longitudinal study in high-risk women
Date
2005
Authors
Schipper, E.
Bolte, A.
Schalkwijk, C.
van Geijn, G.
Dekker, G.
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Journal article
Citation
Journal of Maternal-Fetal and Neonatal Medicine, 2005; 18(5):283-287
Statement of Responsibility
Elbert-Jaap I. Schipper, Antoinette C. Bolte, Casper G. Schalkwijk, Herman P. Van Geijn, and Gustaaf A. Dekker
Conference Name
Abstract
Objective. Tumor necrosis factor-alpha (TNF-) is thought to play a role in immune activation in preeclampsia. The objective of this study was to establish if soluble TNF-receptor I (sTNF-rI) levels relate to the onset and severity of preeclampsia. Methods. Maternal plasma sTNF-rI levels were studied throughout pregnancy in 68 women with a history of severe preeclampsia or intra-uterine growth restriction (IUGR), and primigravidas with chronic hypertension. Data are presented as mean (SD) in ng/ml. Results. In the second trimester there was a significant difference in sTNF-rI levels between preeclamptic pregnancies with and without IUGR (means 1.33 (0.20) and 1.11 (0.15) respectively, p < 0.005). In severe preeclampsia with delivery before 34 weeks of gestation, sTNF-rI levels were higher than in mild preeclampsia in the second and third trimesters (means 1.40 (0.16) vs. 1.16 (0.19), p < 0.02 and 1.82 (0.47) vs. 1.42 (0.22), p < 0.05, respectively). Conclusion. sTNF-rI levels were higher in preeclampsia with fetal involvement, suggesting that increased TNF- production in preeclampsia is related to impaired placentation rather than to the maternal syndrome.
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