Pathogen occurrence and antimicrobial resistance trends among urinary tract infection isolates in the Asia-Western Pacific Region: report from the SENTRY Antimicrobial Surveillance Program, 1998-1999

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dc.contributor.authorTurnidge, J.
dc.contributor.authorBell, J.
dc.contributor.authorBiedenbach, D.
dc.contributor.authorJones, R.
dc.date.issued2002
dc.descriptionCopyright © 2002 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.
dc.description.abstractWorldwide surveillance of antimicrobial resistance among urinary tract pathogens is useful to determine important trends and geographical variation for common Gram-positive and -negative species. The most common causative uropathogens often have intrinsic or acquired resistance mechanisms which include ESBL production among enteric bacilli, multi-drug resistant staphylococci and non-fermentative Gram-negative bacilli such as Pseudomonas aeruginosa and Acinetobacter spp. and vancomycin-resistant Enterococcus spp. This study evaluates pathogen frequency and the resistance rates among urinary tract infection (UTI) pathogens in 14 medical centres in the Asia-Pacific region between 1998 and 1999. The isolates were referred to a central monitor for reference NCCLS broth microdilution testing, identification confirmation and patient demographic analysis. Over 50% of the 958 pathogens were Escherichia coli and Klebsiella spp. followed by P. aeruginosa, Enterococcus spp. and Enterobacter spp. Susceptibility for the three enteric bacilli was high for carbapenems (100%), 'fourth-generation' cephalosporins (cefepime 94.9-98.6%) and amikacin (> or = 93.0%). Beta-lactamase inhibitor compounds were more active against E. coli (piperacillin/tazobactam; > 90% susceptible) than the other two enteric species and all other tested agents had a narrower spectra of activity. The rank order of anti-pseudomonal agents was amikacin (91.5% susceptible)> imipenem > piperacillin/tazobactam > tobramycin > ceftazidime and cefepime (77.4 and 76.4% susceptible, respectively). Susceptibility to quinolones for the P. aeruginosa isolates was only 63.2-67.0%. Only one vancomycin-intermediate Enterococcus spp. (van C phenotype) was detected among the 103 strains tested. Newer fluoroquinolones (gatifloxacin; MIC(50), mg/l) were more potent against enterococci than ciprofloxacin (MIC(50), 2 mg/l) and high-level resistance to aminoglycosides was common (41.7%). The data presented are compared to studies of similar design from other areas which are part of the SENTRY surveillance network.
dc.description.statementofresponsibilityJohn Turnidge, Jan Bell, Douglas J. Biedenbach and Ronald N. Jones
dc.description.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/505521/description#description
dc.identifier.citationInternational Journal of Antimicrobial Agents, 2002; 20(1):10-17
dc.identifier.doi10.1016/S0924-8579(02)00050-X
dc.identifier.issn0924-8579
dc.identifier.issn1872-7913
dc.identifier.orcidTurnidge, J. [0000-0003-4240-5578]
dc.identifier.urihttp://hdl.handle.net/2440/28174
dc.language.isoen
dc.publisherElsevier Science BV
dc.source.urihttps://doi.org/10.1016/s0924-8579(02)00050-x
dc.subjectHumans
dc.subjectGram-Negative Bacteria
dc.subjectGram-Positive Bacteria
dc.subjectUrinary Tract Infections
dc.subjectAnti-Bacterial Agents
dc.subjectMicrobial Sensitivity Tests
dc.subjectDrug Resistance, Microbial
dc.subjectNorth America
dc.subjectAsia
dc.subjectFemale
dc.subjectGlobal Health
dc.titlePathogen occurrence and antimicrobial resistance trends among urinary tract infection isolates in the Asia-Western Pacific Region: report from the SENTRY Antimicrobial Surveillance Program, 1998-1999
dc.typeJournal article
pubs.publication-statusPublished

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