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Neurologic effects of exogenous saccharides: a review of controlled human, animal, and in vitro studies

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dc.contributor.authorNelson, E.D.
dc.contributor.authorRamberg, J.E.
dc.contributor.authorBest, T.
dc.contributor.authorSinnott, R.A.
dc.date.issued2012
dc.description.abstractObjectives: Current research efforts are centered on delineating the novel health benefits of naturally derived saccharides, including growing interest in their abilities to influence neurologic health. We performed a comprehensive review of the literature to consolidate all controlled studies assessing various roles of exogenous saccharide compounds and polysaccharide-rich extracts from plants, fungi, and other natural sources on brain function, with a significant focus on benefits derived from oral intake. Methods: Studies were identified by conducting electronic searches on PubMed and Google Scholar. Reference lists of articles were also reviewed for additional relevant studies. Only articles published in English were included in this review. Results: Six randomized, double-blind, placebo-controlled clinical studies were identified in which consumption of a blend of plant-derived polysaccharides showed positive effects on cognitive function and mood in healthy adults. A separate controlled clinical study observed improvements in well-being with ingestion of a yeast beta-glucan. Numerous animal and in vitro studies have demonstrated the ability of individual saccharide compounds and polysaccharide-rich extracts to modify behavior, enhance synaptic plasticity, and provide neuroprotective effects. Discussion: Although the mechanisms by which exogenous saccharides can influence brain function are not well understood at this time, the literature suggests that certain naturally occurring compounds and polysaccharide-rich extracts show promise, when taken orally, in supporting neurologic health and function. Additional well-controlled clinical studies on larger populations are necessary, however, before specific recommendations can be made.
dc.identifier.citationNutritional Neuroscience, 2012; 15(4):149-162
dc.identifier.doi10.1179/1476830512Y.0000000004
dc.identifier.issn1028-415X
dc.identifier.issn1476-8305
dc.identifier.urihttps://hdl.handle.net/1959.8/125196
dc.language.isoen
dc.publisherManey Publishing
dc.rightsCopyright 2012 W.S. Maney & Son
dc.source.urihttps://doi.org/10.1179/1476830512Y.0000000004
dc.subjectsaccharide
dc.subjectmemory
dc.subjectsynaptic plasticity
dc.subjectprebiotic
dc.subjectneurodegeneration
dc.subjectglucan
dc.subjectfucoidan
dc.titleNeurologic effects of exogenous saccharides: a review of controlled human, animal, and in vitro studies
dc.typeJournal article
pubs.publication-statusPublished
ror.fileinfo12143155020001831 13143153260001831 9915909664601831_53108557020001831.pdf
ror.mmsid9915909664601831

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