Time course of induction of increased human motor cortex excitability by nerve stimulation

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dc.contributor.authorMcKay, D.
dc.contributor.authorBrooker, R.
dc.contributor.authorGiacomin, P.
dc.contributor.authorRidding, M.
dc.contributor.authorMiles, T.
dc.date.issued2002
dc.descriptionCopyright © 2002 Lippincott Williams & Wilkins, Inc.
dc.description.abstractManipulation of afferent input induces changes in the excitability and organisation of human corticomotor representations. These changes are generally short lived, although can be prolonged by repetition. Here, we charted the time-course of the change of motor cortex excitability induced by electrical stimulation of radial and ulnar nerves. Corticomotor excitability was evaluated by measuring the amplitude of the motor evoked potentials in the first dorsal interosseous muscle by transcranial magnetic stimulation of the optimal cortical area. Measurements were carried out before the start of peripheral nerve stimulation, and then during the peripheral nerve stimulation at 15 min intervals over a period of 2 h. The amplitudes of the motor evoked potentials significantly increased during the 2 h period of peripheral nerve stimulation. Cortical excitability peaked after about 45-60 min stimulation. These clear-cut changes in cortical excitability following peripheral nerve stimulation may reveal some of the mechanisms underlying motor learning and cortical plasticity.
dc.description.statementofresponsibilityMcKay, Darrin; Brooker, Raylene; Giacomin, Paul; Ridding, Michael; Miles, Timothy
dc.description.urihttp://journals.lww.com/neuroreport/fulltext/2002/07190/time_course_of_induction_of_increased_human_motor.11.aspx
dc.identifier.citationNeuroReport, 2002; 13(10):1271-1273
dc.identifier.doi10.1097/00001756-200207190-00011
dc.identifier.issn0959-4965
dc.identifier.issn1473-558X
dc.identifier.orcidRidding, M. [0000-0001-5657-9136]
dc.identifier.urihttp://hdl.handle.net/2440/11979
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.source.urihttps://doi.org/10.1097/00001756-200207190-00011
dc.subjectMotor Cortex
dc.subjectRadial Nerve
dc.subjectUlnar Nerve
dc.subjectHumans
dc.subjectElectric Stimulation
dc.subjectEvoked Potentials, Motor
dc.subjectNeuronal Plasticity
dc.subjectMagnetics
dc.subjectAdult
dc.subjectFemale
dc.subjectMale
dc.titleTime course of induction of increased human motor cortex excitability by nerve stimulation
dc.typeJournal article
pubs.publication-statusPublished

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