Current studentsExisting staffContact us
 

Qualitative and quantitative temporal analysis of licit and illicit drugs in wastewater in Australia using liquid chromatography coupled to mass spectrometry

Simple item page
dc.contributor.authorBade, R.
dc.contributor.authorWhite, J.
dc.contributor.authorGerber, C.
dc.date.issued2018
dc.descriptionData source: Electronic supplementary material, https://doi.org/10.1007/s00216-017-0747-2
dc.description.abstractThe combination of qualitative and quantitative bimonthly analysis of pharmaceuticals and illicit drugs using liquid chromatography coupled to mass spectrometry is presented. A liquid chromatography-quadrupole time of flight instrument equipped with Sequential Window Acquisition of all THeoretical fragment-ion spectra (SWATH) was used to qualitatively screen 346 compounds in influent wastewater from two wastewater treatment plants in South Australia over a 14-month period. A total of 100 compounds were confirmed and/or detected using this strategy, with 61 confirmed in all samples including antidepressants (amitriptyline, dothiepin, doxepin), antipsychotics (amisulpride, clozapine), illicit drugs (cocaine, methamphetamine, amphetamine, 3,4-methylenedioxymethamphetamine (MDMA)), and known drug adulterants (lidocaine and tetramisole). A subset of these compounds was also included in a quantitative method, analyzed on a liquid chromatography-triple quadrupole mass spectrometer. The use of illicit stimulants (methamphetamine) showed a clear decrease, levels of opioid analgesics (morphine and methadone) remained relatively stable, while the use of new psychoactive substances (methylenedioxypyrovalerone (MDPV) and Alpha PVP) varied with no visible trend. This work demonstrates the value that high-frequency sampling combined with quantitative and qualitative analysis can deliver.
dc.identifier.citationAnalytical and Bioanalytical Chemistry, 2018; 410(2):529-542
dc.identifier.doi10.1007/s00216-017-0747-2
dc.identifier.issn1618-2642
dc.identifier.issn1618-2650
dc.identifier.urihttps://hdl.handle.net/11541.2/129665
dc.language.isoen
dc.publisherSpringer
dc.relation.fundingDrug and Alcohol Services South Australia, SA Health
dc.relation.fundingThyne Reid Foundation
dc.rightsCopyright 2017 Springer
dc.source.urihttps://doi.org/10.1007/s00216-017-0747-2
dc.subjectnew psychoactive substances
dc.subjectwastewater
dc.subjectillicit drugs
dc.subjectpharmaceuticals
dc.subjecttriple quadrupole
dc.subjecthigh resolution mass spectrometry
dc.titleQualitative and quantitative temporal analysis of licit and illicit drugs in wastewater in Australia using liquid chromatography coupled to mass spectrometry
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9916166602401831

Files

Collections