3-Amino-2-hydroxy-N-(4-nitrophenyl)-propanesulphonamide, a new class of GABAB receptor antagonist in central and peripheral preparations

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dc.contributor.authorKerr, D.
dc.contributor.authorOng, J.
dc.contributor.authorHughes, R.
dc.contributor.authorPrager, R.
dc.date.issued1995
dc.description.abstractRacemic 3-amino-2-hydroxy-N-(4-nitrophenyl)-propanesulphonamide (AHPNS), a sulphonamide analog of GABA, reversibly and competitively antagonised the concentration-dependent depression of cholinergic twitch contractions by baclofen, in the electrically stimulated guinea-pig isolated ileum, with a pA2 of 4.0 +/- 0.2. In the rat neocortex, maintained in Mg(2+)-free medium, AHPNS (100-500 microM) also reversibly antagonised the baclofen (10 microM)-induced suppression of spontaneous discharges. AHPNS is a new class of GABAB receptor antagonist that has central and peripheral blocking actions.
dc.identifier.citationEuropean Journal of Pharmacology, 1995; 294(1):349-352
dc.identifier.doi10.1016/0014-2999(95)00688-5
dc.identifier.issn0014-2999
dc.identifier.issn1879-0712
dc.identifier.orcidOng, J. [0000-0002-0958-460X]
dc.identifier.urihttp://hdl.handle.net/2440/5987
dc.language.isoen
dc.publisherNorth Holland
dc.source.urihttps://doi.org/10.1016/0014-2999(95)00688-5
dc.subjectMuscle, Smooth
dc.subjectIleum
dc.subjectCentral Nervous System
dc.subjectCerebral Cortex
dc.subjectPeripheral Nervous System
dc.subjectParasympathetic Nervous System
dc.subjectAnimals
dc.subjectGuinea Pigs
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectMagnesium
dc.subjectSulfonamides
dc.subjectBaclofen
dc.subjectGABA Agonists
dc.subjectElectric Stimulation
dc.subjectMuscle Contraction
dc.subjectMale
dc.subjectGABA-B Receptor Agonists
dc.subjectGABA-B Receptor Antagonists
dc.subjectIn Vitro Techniques
dc.title3-Amino-2-hydroxy-N-(4-nitrophenyl)-propanesulphonamide, a new class of GABAB receptor antagonist in central and peripheral preparations
dc.typeJournal article
pubs.publication-statusPublished

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