The MerR/NmlR Family Transcription Factor of Streptococcus pneumoniae responds to carbonyl stress and modulates hydrogen peroxide production

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dc.contributor.authorPotter, A.
dc.contributor.authorKidd, S.
dc.contributor.authorMcEwan, A.
dc.contributor.authorPaton, J.
dc.date.issued2010
dc.description.abstractThe NmlRsp transcription factor of Streptococcus pneumoniae is shown to induce adhC (alcohol dehydrogenase) expression in the presence of both formaldehyde and methylglyoxal. nmlRsp and adhC mutant strains display altered and opposite aerobic growth phenotypes. The nmlRsp strain exhibits increased resistance to high oxygen tension, attributable to decreased H2O2 production, which correlated with downregulation of carbamoyl phosphate synthase (carB). This indicates a possible role for AdhC in aldehyde metabolism and a broader role for NmlRsp in the regulation of carbon metabolism.
dc.description.statementofresponsibilityAdam J. Potter, Stephen P. Kidd, Alastair G. McEwan and James C. Paton
dc.identifier.citationJournal of Bacteriology, 2010; 192(15):4063-4066
dc.identifier.doi10.1128/JB.00383-10
dc.identifier.issn0021-9193
dc.identifier.issn1098-5530
dc.identifier.orcidKidd, S. [0000-0002-2118-1651]
dc.identifier.orcidPaton, J. [0000-0001-9807-5278]
dc.identifier.urihttp://hdl.handle.net/2440/60636
dc.language.isoen
dc.publisherAmer Soc Microbiology
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/565526
dc.rightsCopyright © 2010, American Society for Microbiology. All Rights Reserved.
dc.source.urihttps://doi.org/10.1128/jb.00383-10
dc.subjectStreptococcus pneumoniae
dc.subjectHydrogen Peroxide
dc.subjectOxygen
dc.subjectFormaldehyde
dc.subjectPyruvaldehyde
dc.subjectAlcohol Dehydrogenase
dc.subjectBacterial Proteins
dc.subjectDNA-Binding Proteins
dc.subjectTranscription Factors
dc.subjectDown-Regulation
dc.subjectGene Expression Regulation, Bacterial
dc.subjectOxidative Stress
dc.subjectMultigene Family
dc.titleThe MerR/NmlR Family Transcription Factor of Streptococcus pneumoniae responds to carbonyl stress and modulates hydrogen peroxide production
dc.typeJournal article
pubs.publication-statusPublished

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