13C-Urea breath test: Reproducibility and association with the severity of Helicobacter pylori-associated antral gastritis

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dc.contributor.authorMatthews, G.
dc.contributor.authorCummins, A.
dc.contributor.authorLawrence, A.
dc.contributor.authorJohnson, B.
dc.contributor.authorCampbell, F.
dc.contributor.authorButler, R.
dc.date.issued2005
dc.description.abstract<h4>Background</h4>The purpose of the present paper was to assess the reproducibility of the (13)C-urea breath test ((13)C-UBT) and its ability to reflect the level of Helicobacter pylori-associated inflammation.<h4>Methods</h4>Asymptomatic H. pylori-positive subjects (n = 21) performed the (13)C-UBT six times. The H. pylori-positive symptomatic subjects (n = 55) performed the (13)C-UBT and had antral biopsies taken for histopathology, culture, urease activity assay and myeloperoxidase activity assay.<h4>Results</h4>No significant intraindividual variation in (13)C-UBT results were observed for the asymptomatic subjects. The (13)C-UBT results were significantly higher in symptomatic subjects with a moderate to severe gastritis compared to a mild gastritis and to no inflammation (34.5 +/- 4.4 vs 17.7 +/- 2.8 vs 1.7 +/- 0.1, respectively, P < 0.01). The (13)C-UBT results significantly correlated with urease (r = 0.55) and myeloperoxidase activity (r = 0.82) but not with bacterial load. conclusion: The (13)C-UBT is a reproducible determinant of H. pylori infection and non-invasively assesses the severity of antral inflammation.
dc.description.statementofresponsibilityMatthews, Geoffrey M; Cummins, Adrian G; Lawrence, Andrew; Johnson, Bruce; Campbell, Fiona; Butler, Ross N
dc.identifier.citationJournal of Gastroenterology and Hepatology (Australia), 2005; 20(2):270-274
dc.identifier.doi10.1111/j.1440-1746.2005.03547.x
dc.identifier.issn0815-9319
dc.identifier.issn1440-1746
dc.identifier.orcidCummins, A. [0000-0003-3115-9498]
dc.identifier.urihttp://hdl.handle.net/2440/27485
dc.language.isoen
dc.publisherBlackwell Publishing Asia
dc.source.urihttps://doi.org/10.1111/j.1440-1746.2005.03547.x
dc.subjectHumans
dc.subjectHelicobacter pylori
dc.subjectHelicobacter Infections
dc.subjectUrea
dc.subjectPeroxidase
dc.subjectBreath Tests
dc.subjectGastroscopy
dc.subjectSeverity of Illness Index
dc.subjectSensitivity and Specificity
dc.subjectReproducibility of Results
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.title13C-Urea breath test: Reproducibility and association with the severity of Helicobacter pylori-associated antral gastritis
dc.typeJournal article
pubs.publication-statusPublished

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