Uncovering GPCR heteromer-biased ligands
Date
2010
Authors
Mustafa, S.
Ayoub, M.
Pfleger, K.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Drug Discovery Today: Technologies, 2010; 7(1):e77-e85
Statement of Responsibility
Sanam Mustafa, Mohammed Akli Ayoub, Kevin D.G. Pfleger
Conference Name
Abstract
The formation of complexes involving different G-protein-coupled receptors (GPCRs) is now an established phenomenon, termed heteromerization. The relevance of higher order structures, in particular heteromerization, has been demonstrated by differential pharmacology displayed by GPCR heteromers compared to monomers/homomers of the respective constituent receptor units. The concepts of heteromerization and heteromer-selective/biased ligands introduce exciting opportunities for enhancing signal specificity and therefore have the potential to play a crucial role in future drug discovery. © 2010 Elsevier Ltd. All rights reserved.
School/Discipline
Dissertation Note
Provenance
Description
Access Status
Rights
© 2010 Elsevier Ltd.