Osteocytes: the master cells in bone remodelling

Simple item page
dc.contributor.authorPrideaux, M.
dc.contributor.authorFindlay, D.
dc.contributor.authorAtkins, G.
dc.date.issued2016
dc.description.abstractBone remodelling is an essential process for shaping and maintaining bone mass in the mature skeleton. During our lifetime bone is constantly being removed by osteoclasts and new bone is formed by osteoblasts. The activities of osteoclasts and osteoblasts must be regulated under a strict balance to ensure that bone homeostasis is maintained. Osteocytes, which form an extensive, multi-functional syncytium throughout the bone, are increasingly considered to be the cells that maintain this balance. Current research is elucidating key signalling pathways by which the osteocyte exerts control over the other cell types in bone and over its own activities, and potential ways in which these pathways may be exploited therapeutically.
dc.description.statementofresponsibilityMatthew Prideaux, David M Findlay and Gerald J Atkins
dc.identifier.citationCurrent Opinion in Pharmacology, 2016; 28:24-30
dc.identifier.doi10.1016/j.coph.2016.02.003
dc.identifier.issn1471-4892
dc.identifier.issn1471-4973
dc.identifier.orcidAtkins, G. [0000-0002-3123-9861]
dc.identifier.urihttp://hdl.handle.net/2440/100146
dc.language.isoen
dc.publisherElsevier
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1047796
dc.rights© 2016 Elsevier Ltd. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.coph.2016.02.003
dc.subjectBone and Bones
dc.subjectOsteoclasts
dc.subjectOsteoblasts
dc.subjectOsteocytes
dc.subjectAnimals
dc.subjectHumans
dc.subjectBone Remodeling
dc.subjectSignal Transduction
dc.subjectHomeostasis
dc.titleOsteocytes: the master cells in bone remodelling
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Medicine publications