Simple method for assaying colistin methanesulfonate in plasma and urine using high-performance liquid chromatography
Date
2002
Authors
Li, J.
Milne, R.
Nation, R.
Turnidge, J.
Coulthard, K.
Valentine, J.
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Advisors
Journal Title
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Volume Title
Type:
Journal article
Citation
Antimicrobial Agents and Chemotherapy, 2002; 46(10):3304-3307
Statement of Responsibility
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Abstract
A simple and sensitive high-performance liquid chromatographic method is described for the determination of colistimethate sodium in plasma and urine. The accuracy and reproducibility was within 10.1 and 11.2% with rat plasma and urine, respectively. Several commonly coadministered antibacterial agents do not interfere with the assay.