Hospitalisation with infection, asthma and allergy in Kawasaki disease patients and their families: Genealogical analysis using linked population data

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dc.contributor.authorWebster, R.
dc.contributor.authorCarter, K.
dc.contributor.authorWarrington, N.
dc.contributor.authorLoh, A.
dc.contributor.authorZaloumis, S.
dc.contributor.authorKuijpers, T.
dc.contributor.authorPalmer, L.
dc.contributor.authorBurgner, D.
dc.contributor.editorDubé, M.-P.
dc.date.issued2011
dc.description.abstractBackground: Kawasaki disease results from an abnormal immunological response to one or more infectious triggers. We hypothesised that heritable differences in immune responses in Kawasaki disease-affected children and their families would result in different epidemiological patterns of other immune-related conditions. We investigated whether hospitalisation for infection and asthma/allergy were different in Kawasaki disease-affected children and their relatives. Methods/Major Findings: We used Western Australian population-linked health data from live births (1970–2006) to compare patterns of hospital admissions in Kawasaki disease cases, age- and sex-matched controls, and their relatives. There were 295 Kawasaki disease cases and 598 age- and sex-matched controls, with 1,636 and 3,780 relatives, respectively. Compared to controls, cases were more likely to have been admitted at least once with an infection (cases, 150 admissions (50.8%) vs controls, 210 admissions (35.1%); odds ratio (OR) = 1.9, 95% confidence interval (CI) 1.4–2.6, P = 7.2×10−6), and with asthma/allergy (cases, 49 admissions (16.6%) vs controls, 42 admissions (7.0%); OR = 2.6, 95% CI 1.7–4.2, P = 1.3×10−5). Cases also had more admissions per person with infection (cases, median 2 admissions, 95% CI 1–5, vs controls, median 1 admission, 95% CI 1–4, P = 1.09×10−5). The risk of admission with infection was higher in the first degree relatives of Kawasaki disease cases compared to those of controls, but the differences were not significant. Conclusion: Differences in the immune phenotype of children who develop Kawasaki disease may influence the severity of other immune-related conditions, with some similar patterns observed in relatives. These data suggest the influence of shared heritable factors in these families.
dc.description.statementofresponsibilityRebecca J. Webster, Kim W. Carter, Nicole M. Warrington, Angeline M. Loh, Sophie Zaloumis, Taco W. Kuijpers, Lyle J. Palmer, David P. Burgner
dc.identifier.citationPLoS One, 2011; 6(11):e28004-1-e28004-7
dc.identifier.doi10.1371/journal.pone.0028004
dc.identifier.issn1932-6203
dc.identifier.issn1932-6203
dc.identifier.orcidPalmer, L. [0000-0002-1628-3055]
dc.identifier.urihttp://hdl.handle.net/2440/84934
dc.language.isoen
dc.publisherPublic Library of Science
dc.rights© 2011 Webster et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.source.urihttps://doi.org/10.1371/journal.pone.0028004
dc.subjectHumans
dc.subjectCommunicable Diseases
dc.subjectAsthma
dc.subjectMucocutaneous Lymph Node Syndrome
dc.subjectHospitalization
dc.subjectIncidence
dc.subjectLinear Models
dc.subjectCase-Control Studies
dc.subjectFamily
dc.subjectPublic Health
dc.subjectAge of Onset
dc.subjectAge Distribution
dc.subjectGenealogy and Heraldry
dc.subjectAdolescent
dc.subjectAdult
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectInfant
dc.subjectInfant, Newborn
dc.subjectWestern Australia
dc.subjectFemale
dc.subjectMale
dc.subjectDatabases as Topic
dc.subjectYoung Adult
dc.titleHospitalisation with infection, asthma and allergy in Kawasaki disease patients and their families: Genealogical analysis using linked population data
dc.typeJournal article
pubs.publication-statusPublished

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