Current studentsExisting staffContact us
 

Anaplerotic roles of pyruvate carboxylase in mammalian tissues

Simple item page
dc.contributor.authorJitrapakdee, S.
dc.contributor.authorVidal-Puig, A.
dc.contributor.authorWallace, J.
dc.date.issued2006
dc.descriptionThe original publication is available at www.springerlink.com © Springer
dc.description.abstractPyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate. PC serves an anaplerotic role for the tricarboxylic acid cycle, when intermediates are removed for different biosynthetic purposes. In liver and kidney, PC provides oxaloacetate for gluconeogenesis. In adipocytes PC is involved in de novo fatty acid synthesis and glyceroneogenesis, and is regulated by the peroxisome proliferator-activated receptor-γ, suggesting that PC is involved in the metabolic switch controlling fuel partitioning toward lipogenesis. In islets, PC is necessary for glucose-induced insulin secretion by providing oxaloacetate to form malate that participates in the ‘pyruvate/malate cycle’ to shuttle 3C or 4C between mitochondria and cytoplasm. Hyperglycemia and hyperlipidemia impair this cycle and affect glucose-stimulated insulin release. In astrocytes, PC is important for de novo synthesis of glutamate, an important excitatory neurotransmitter supplied to neurons. Transcriptional studies of the PC gene pinpoint some transcription factors that determine tissue-specific expression.
dc.description.statementofresponsibilityS. Jitrapakdeea, A.Vidal-Puig, and J. C.Wallace
dc.identifier.citationCellular and Molecular Life Sciences, 2006; 63(7-8):843-854
dc.identifier.doi10.1007/s00018-005-5410-y
dc.identifier.issn1420-682X
dc.identifier.issn1420-9071
dc.identifier.urihttp://hdl.handle.net/2440/23975
dc.language.isoen
dc.publisherBirkhauser Verlag Ag
dc.source.urihttps://doi.org/10.1007/s00018-005-5410-y
dc.subjectpyruvate carboxylase
dc.subjectbiotin carboxylase
dc.subjectglucose-induced insulin secretion
dc.subjectpyruvate
dc.subjectmalate shuttle
dc.subjectcitrate shuttle
dc.subjecttype 2 diabetes
dc.subjectlipogenesis
dc.subjectglyceroneogenesis
dc.subjectastrocytes
dc.subjectglutamate synthesis
dc.titleAnaplerotic roles of pyruvate carboxylase in mammalian tissues
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Molecular and Biomedical Science publications