Young-onset colorectal cancer in New South Wales: a population-based study

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dc.contributor.authorBoyce, S.
dc.contributor.authorNassar, N.
dc.contributor.authorLee, C.
dc.contributor.authorSuen, M.
dc.contributor.authorZahrani, S.
dc.contributor.authorGladman, M.
dc.date.issued2016
dc.description.abstractObjective: Australia has the highest incidence of colorectal cancer (CRC) in the world. The incidence of young-onset CRC (yCRC) is increasing in developed nations. Our aim was to determine the incidence of yCRC in New South Wales, the demographic and clinico-pathological characteristics of these patients, and their survival. Design, setting, participants: A population-based cohort study of all cases of CRC diagnosed in NSW during 2001-2008. Data on newly diagnosed cases of CRC were obtained from the NSW Central Cancer Registry; mortality data were obtained from the NSW Registry of Births Deaths and Marriages (to 2012). The characteristics and tumour-related factors of patients under 50 years of age (yCRC) were compared with those for patients aged 50 years or more. Main outcome measures: Current incidence of yCRC and trends in incidence; 5-year cancer-specific survival rates and risks of death compared with older patients. Results: 32 178 patients were diagnosed with CRC, including 2001 (6.2%) with yCRC. The incidence of yCRC was unchanged across the study period (2001, 13.7 cases per 100 000 population; 2008, 11.8 per 100 000; P = 0.26). Rectal cancer was more frequent in yCRC than in older patients (34.4% v 26.0%), as was distant disease (21.2% v 15.3%). However, 5-year cancer-specific survival was greater for patients with yCRC (68.8%; 95% CI, 66.2-71.2%) than for older patients (66.3%; 95% CI, 65.6-67.0%; P < 0.001). Conclusions: The incidence of yCRC did not increase in NSW during 2001-2008. Despite more advanced disease at presentation, cancer-specific survival was better than for older patients with CRC.
dc.description.statementofresponsibilityStephen Boyce, Natasha Nassar, Cathy Yuen Yi Lee, Michael KL Suen, Saleh Al Zahrani, Marc A Gladman
dc.identifier.citationMedical Journal of Australia, 2016; 205(10):465-470
dc.identifier.doi10.5694/mja16.00237
dc.identifier.issn0025-729X
dc.identifier.issn1326-5377
dc.identifier.orcidGladman, M. [0000-0001-8412-9570]
dc.identifier.urihttp://hdl.handle.net/2440/111740
dc.language.isoen
dc.publisherAustralasian Medical Publishing Company
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1067066
dc.rights© 2016 AMPCo Pty Ltd. Produced with Elsevier B.V. All rights reserved.
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84996490868&doi=10.5694/mja16.00237&partnerID=40&md5=1c44a15bf895d0d9966b695e17d3e29a
dc.subjectHumans
dc.subjectColorectal Neoplasms
dc.subjectMass Screening
dc.subjectRegistries
dc.subjectIncidence
dc.subjectSurvival Rate
dc.subjectMultivariate Analysis
dc.subjectProportional Hazards Models
dc.subjectCohort Studies
dc.subjectAge of Onset
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectNew South Wales
dc.subjectFemale
dc.subjectMale
dc.subjectKaplan-Meier Estimate
dc.titleYoung-onset colorectal cancer in New South Wales: a population-based study
dc.typeJournal article
pubs.publication-statusPublished

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