Investigation of radiosensitization mechanisms using gold and aluminium nanoparticles under clinical beam radiation in the 4T1 mouse model of breast cancer /
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(Published version)
Date
2024
Authors
Nazarizadeh, Ali
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thesis
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Abstract
High atomic number nanoparticles are being investigated as radiosensitizers to enhance radiotherapy. Although a couple of these nano-radiosensitizers have progressed to clinical trials and are on the market in Europe, their mechanisms of action still need to be elucidated. While the conventional theory emphasizes the physical interactions between the nanoparticles and X-rays, we hypothesize that the biological interactions between nanoparticles and tumor cells appear to play a more important role than the physical X-ray interactions in radiobiological responses. Building on our previous discoveries, we were motivated to further investigate the radiosensitizing mechanisms of gold nanoparticles (Au-NPs) with high atomic number compared to immunogenic aluminium nanoparticles (Al-NPs) with low atomic number.
School/Discipline
University of South Australia. UniSA STEM.
UniSA STEM
UniSA STEM
Dissertation Note
Thesis (PhD(Biomaterials, Engineering and Nanomedicine))--University of South Australia, 2024.
Provenance
Copyright 2024 Ali Nazarizadeh.
Description
1 ethesis (xviii, 168 pages) :
colour illustrations, photographs, charts (chiefly colour)
Includes bibliographical references (pages 135-154)
colour illustrations, photographs, charts (chiefly colour)
Includes bibliographical references (pages 135-154)
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