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A novel magnesium ion-incorporating dual-crosslinked hydrogel to improve bone scaffold-mediated osteogenesis and angiogenesis

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dc.contributor.authorZhang, X.
dc.contributor.authorHuang, P.
dc.contributor.authorJiang, G.
dc.contributor.authorZhang, M.
dc.contributor.authorYu, F.
dc.contributor.authorDong, X.
dc.contributor.authorWang, L.
dc.contributor.authorChen, Y.
dc.contributor.authorZhang, W.
dc.contributor.authorQi, Y.
dc.contributor.authorLi, W.
dc.contributor.authorZeng, H.
dc.date.issued2021
dc.descriptionData source: Supplementary data, https://doi.org/10.1016/j.msec.2021.111868
dc.description.abstractOsteogenesis is closely complemented by angiogenesis during the bone regeneration process. The development of functional hydrogel bone substitutes that mimic the extracellular matrix is a promising strategy for bone tissue engineering. However, the development of scaffold materials tailored to exhibit sufficient biomechanics, biodegradability, and favorable osteogenic and angiogenic activity continue to present a great challenge. Herein, we prepared a novel magnesium ion-incorporating dual-crosslinked hydrogel through the photocrosslinking of gelatin methacryloyl (GelMA), thiolated chitosan (TCS) and modified polyhedral oligomeric silsesquioxane (POSS) nanoparticles, and active Mg<sup>2+</sup> ions were then introduced into system via coordination bonds of MgS, which can be tailored to possess superior mechanical strength, a stable network structure and more suitable pore size and degradation properties. The fabricated GelMA/TCS/POSS-Mg hydrogels effectively promoted cell adhesion, spreading, and proliferation, demonstrating that the introduction of POSS and Mg<sup>2+</sup> not only stimulates the osteogenic differentiation of BMSCs but also promotes angiogenesis both in vitro and in vivo, thereby facilitating subsequent bone regeneration in calvarial defects of rats. Taken together, the results of this study indicate that the GelMA/TCS/POSS-Mg hydrogel has promising potential for repairing bone defects by promoting cell adhesion, osteogenesis and vascularization.
dc.identifier.citationMaterials Science and Engineering C, 2021; 121(111868):1-13
dc.identifier.doi10.1016/j.msec.2021.111868
dc.identifier.issn0928-4931
dc.identifier.issn1873-0191
dc.identifier.urihttps://hdl.handle.net/11541.2/147234
dc.language.isoen
dc.publisherElsevier
dc.rightsCopyright 2021 Osteogenesis is closely complemented by angiogenesis during the bone regeneration process. The development of functional hydrogel bone substitutes that mimic the extracellular matrix is a promising strategy for bone tissue engineering. However, the development of scaffold materials tailored to exhibit sufficient biomechanics, biodegradability, and favorable osteogenic and angiogenic activity continue to present a great challenge. Herein, we prepared a novel magnesium ion-incorporating dual-crosslinked hydrogel through the photocrosslinking of gelatin methacryloyl (GelMA), thiolated chitosan (TCS) and modified polyhedral oligomeric silsesquioxane (POSS) nanoparticles, and active Mg2+ ions were then introduced into system via coordination bonds of Mg–S, which can be tailored to possess superior mechanical strength, a stable network structure and more suitable pore size and degradation properties. The fabricated GelMA/TCS/POSS-Mg hydrogels effectively promoted cell adhesion, spreading, and proliferation, demonstrating that the introduction of POSS and Mg2+ not only stimulates the osteogenic differentiation of BMSCs but also promotes angiogenesis both in vitro and in vivo, thereby facilitating subsequent bone regeneration in calvarial defects of rats. Taken together, the results of this study indicate that the GelMA/TCS/POSS-Mg hydrogel has promising potential for repairing bone defects by promoting cell adhesion, osteogenesis and vascularization
dc.source.urihttps://doi.org/10.1016/j.msec.2021.111868
dc.subjectbone regeneration
dc.subjectmagnesium ion-incorporating dual-crosslinked hydrogel
dc.subjectPOSS
dc.titleA novel magnesium ion-incorporating dual-crosslinked hydrogel to improve bone scaffold-mediated osteogenesis and angiogenesis
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9916480201701831

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