Intensity modulated radiation therapy dose painting for localized prostate cancer using¹¹C-choline positron emission tomography scans

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dc.contributor.authorChang, J.
dc.contributor.authorLim Joon, D.
dc.contributor.authorLee, S.
dc.contributor.authorGong, S.
dc.contributor.authorAnderson, N.
dc.contributor.authorScott, A.
dc.contributor.authorDavis, I.
dc.contributor.authorClouston, D.
dc.contributor.authorBolton, D.
dc.contributor.authorHamilton, C.
dc.contributor.authorKhoo, V.
dc.date.issued2012
dc.description.abstractPURPOSE: To demonstrate the technical feasibility of intensity modulated radiation therapy (IMRT) dose painting using¹¹C-choline positron emission tomography PET scans in patients with localized prostate cancer. METHODS AND MATERIALS: This was an RT planning study of 8 patients with prostate cancer who had ¹¹C-choline PET scans prior to radical prostatectomy. Two contours were semiautomatically generated on the basis of the PET scans for each patient: 60% and 70% of the maximum standardized uptake values (SUV(60%) and SUV(70%)). Three IMRT plans were generated for each patient: PLAN(78), which consisted of whole-prostate radiation therapy to 78 Gy; PLAN(78-90), which consisted of whole-prostate RT to 78 Gy, a boost to the SUV(60%) to 84 Gy, and a further boost to the SUV(70%) to 90 Gy; and PLAN(72-90), which consisted of whole-prostate RT to 72 Gy, a boost to the SUV(60%) to 84 Gy, and a further boost to the SUV(70%) to 90 Gy. The feasibility of these plans was judged by their ability to reach prescription doses while adhering to published dose constraints. Tumor control probabilities based on PET scan-defined volumes (TCP(PET)) and on prostatectomy-defined volumes (TCP(path)), and rectal normal tissue complication probabilities (NTCP) were compared between the plans. RESULTS: All plans for all patients reached prescription doses while adhering to dose constraints. TCP(PET) values for PLAN(78), PLAN(78-90), and PLAN(72-90) were 65%, 97%, and 96%, respectively. TCP(path) values were 71%, 97%, and 89%, respectively. Both PLAN(78-90) and PLAN(72-90) had significantly higher TCP(PET) (P=.002 and .001) and TCP(path) (P<.001 and .014) values than PLAN(78). PLAN(78-90) and PLAN(72-90) were not significantly different in terms of TCP(PET) or TCP(path). There were no significant differences in rectal NTCPs between the 3 plans. CONCLUSIONS: IMRT dose painting for localized prostate cancer using (11)C-choline PET scans is technically feasible. Dose painting results in higher TCPs without higher NTCPs.
dc.description.statementofresponsibilityJoe H. Chang, Daryl Lim Joon, Sze Ting Lee, Sylvia J. Gong, Nigel J. Anderson, Andrew M. Scott, Ian D. Davis, David Clouston, Damien Bolton, Christopher S. Hamilton, Vincent Khoo
dc.identifier.citationInternational Journal of Radiation Oncology Biology Physics, 2012; 83(5):e691-e696
dc.identifier.doi10.1016/j.ijrobp.2012.01.087
dc.identifier.issn0360-3016
dc.identifier.issn1879-355X
dc.identifier.urihttp://hdl.handle.net/2440/105797
dc.language.isoen
dc.publisherElsevier
dc.rightsCopyright © 2012 Elsevier Inc. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.ijrobp.2012.01.087
dc.subjectDose painting; C-choline, Positron emission tomography; prostrate cancer; IMRT
dc.titleIntensity modulated radiation therapy dose painting for localized prostate cancer using¹¹C-choline positron emission tomography scans
dc.title.alternativeIntensity modulated radiation therapy dose painting for localized prostate cancer using(11)C-choline positron emission tomography scans
dc.typeJournal article
pubs.publication-statusPublished

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