The impact of obesity and uncontrolled asthma during pregnancy on metabolic and inflammatory pathways

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dc.contributor.authorBhaumik, S.
dc.contributor.authorLockett, J.
dc.contributor.authorSaif, Z.
dc.contributor.authorLai, A.
dc.contributor.authorSalomon, C.
dc.contributor.authorWhitehead, J.
dc.contributor.authorClifton, V.L.
dc.date.issued2023
dc.descriptionPublished online: 25 Oct 2022
dc.description.abstractAsthma and obesity are both inflammatory complications of pregnancy and when combined contribute to an increased risk of uncontrolled asthma during pregnancy and poor perinatal outcomes. Our previous work has identified the presence of maternal asthma is associated with a proinflammatory milieu in the placenta and reduced fetal growth. The current study was designed to determine the relationships between immunomodulatory metabolic pathways and inflammation and establish whether these pathways are associated with uncontrolled asthma in obese pregnant women.Fifty-three obese (BMI >30) pregnant women were recruited prospectively. Participants were classified as having no asthma, controlled asthma, and uncontrolled asthma based on a doctor diagnosis and assessment using the Asthma Control Questionnaire (ACQ). Circulating plasma concentrations of metabolic hormones leptin, adiponectin, insulin, glucose, and extracellular vesicle (EVs) associated cytokines were measured at 18- and 36-weeks gestation.Concentrations of metabolic and inflammatory markers among obese participants with or without asthma were not significantly different throughout gestation. However total adiponectin concentrations increased as gestation progressed in obese, non-asthmatic women but did not increase in women with asthma. Plasma adiponectin and leptin levels in women with uncontrolled asthma were positively correlated with EV inflammatory markers including GM-CSF, IL-6, TNFα and IFNγ protein.This study demonstrated that most metabolic markers remain unchanged with the presence and severity of asthma in obese pregnant women. However, differences in the associations between metabolic and inflammatory pathways were observed in women with asthma and may be one of the mechanisms contributing to uncontrolled asthma in obese pregnant women.
dc.description.statementofresponsibilitySreeparna Bhaumik, Jack Lockett, Zarqa Saif, Andrew Lai, Carlos Salomon, Jonathan P. Whitehead, Vicki L. Clifton
dc.identifier.citationJournal of Asthma, 2023; 60(6):1141-1152
dc.identifier.doi10.1080/02770903.2022.2134794
dc.identifier.issn0277-0903
dc.identifier.issn1532-4303
dc.identifier.orcidClifton, V.L. [0000-0002-4892-6748]
dc.identifier.urihttps://hdl.handle.net/2440/136834
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1041918
dc.rights© 2022 Taylor & Francis Group, LLC
dc.source.urihttps://doi.org/10.1080/02770903.2022.2134794
dc.subjectUncontrolled asthma
dc.subjectobesity
dc.subjectpregnancy
dc.subjectinflammation
dc.subjectcytokines
dc.titleThe impact of obesity and uncontrolled asthma during pregnancy on metabolic and inflammatory pathways
dc.typeJournal article
pubs.publication-statusPublished

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