Current studentsExisting staffContact us
 

Relationship between calcium absorption and plasma dehydroepiandrosterone sulphate (DHEAS) in healthy males

Simple item page
dc.contributor.authorChen, R.
dc.contributor.authorNordin, B.
dc.contributor.authorNeeds, A.
dc.contributor.authorScopacasa, F.
dc.contributor.authorWishart, J.
dc.contributor.authorMorris, H.
dc.contributor.authorHorowitz, M.
dc.date.issued2008
dc.description.abstractContext Impaired gut sensitivity to 1,25-dihydroxyvitamin D (1,25(OH)2D), leading to reduced intestinal calcium absorption, has been reported in older men and women. While this phenomenon in postmenopausal women has been attributed to oestrogen deficiency, it is unclear whether the same observation in older men correlates with the age-related decline in androgen concentrations. Objective To examine the relationship between androgens and intestinal calcium absorption in older men. Design Cross-sectional study on 55 healthy male volunteers, divided into younger (n = 27) and older (n = 28) groups separated according to the median age of 59 years. Main outcome measures Calcium absorption, total and free (calculated) testosterone, dehydroepiandrosterone sulphate (DHEAS), SHBG, and 1,25(OH)2D, among others, were measured. Results Calcium absorption, free testosterone and DHEAS, but not 1,25(OH)2D, declined significantly with age. After adjusting for age and body mass index, stepwise regression showed that 1,25(OH)2D and serum albumin were the only significant determinants of calcium absorption in younger men, while the sole determinant in older men was DHEAS, not testosterone. Residual deviations from the regression of calcium absorption on 1,25(OH)2D, reflecting the efficiency of 1,25(OH)2D-induced calcium absorption, was positively correlated with DHEAS (r = 0·27, P = 0·027). Conclusions DHEAS is an independent determinant of calcium absorption in older men, although its manner of influence is, as yet, undefined. The age-related decline of DHEAS may, partly, account for the observed 'intestinal resistance to 1,25(OH)2D' in older men.
dc.description.statementofresponsibilityR.Y.T. Chen, B.E.C. Nordin, A.G. Need, F. Scopacasa, J. Wishart, H.A. Morris and M. Horowitz
dc.identifier.citationClinical Endocrinology, 2008; 69(6):864-869
dc.identifier.doi10.1111/j.1365-2265.2008.03272.x
dc.identifier.issn0300-0664
dc.identifier.issn1365-2265
dc.identifier.orcidMorris, H. [0000-0002-2745-3750]
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]
dc.identifier.urihttp://hdl.handle.net/2440/53264
dc.language.isoen
dc.publisherBlackwell Science Ltd
dc.source.urihttps://doi.org/10.1111/j.1365-2265.2008.03272.x
dc.subjectHumans
dc.subjectCalcium, Dietary
dc.subjectDehydroepiandrosterone Sulfate
dc.subjectTestosterone
dc.subjectVitamin D
dc.subjectSex Hormone-Binding Globulin
dc.subjectRegression Analysis
dc.subjectIntestinal Absorption
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectMale
dc.titleRelationship between calcium absorption and plasma dehydroepiandrosterone sulphate (DHEAS) in healthy males
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Medicine publications