Does computerized cognitive behavioral therapy help people with inflammatory bowel disease? A randomized controlled trial

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dc.contributor.authorMcCombie, A.
dc.contributor.authorGearry, R.
dc.contributor.authorAndrews, J.
dc.contributor.authorMulder, R.
dc.contributor.authorMikocka-Walus, A.
dc.date.issued2016
dc.description.abstractCognitive behavioral therapy may be useful for improving health-related quality of life (HRQOL) of at least some patients with inflammatory bowel disease (IBD), especially those with psychiatric comorbidities. However, cognitive behavioral therapy can be difficult to access. These difficulties can be overcome by computerized cognitive behavioral therapy (CCBT). This is a randomized controlled trial of a self-administered CCBT intervention for patients with IBD focused on improving HRQOL. It is hypothesized that CCBT completers will have an improved HRQOL relative to people not allocated to CCBT.Patients with IBD were randomly allocated to CCBT (n = 113) versus treatment as usual (n = 86). The IBD Questionnaire at 12 weeks after baseline was the primary outcome, while generic HRQOL, anxiety, depression, coping strategies, perceived stress, and IBD symptoms were secondary outcomes. Outcomes were also measured at 6 months after baseline. Predictors of dropout were also determined.Twenty-nine CCBT participants (25.7%) completed the CCBT. The IBD Questionnaire was significantly increased at 12 weeks in CCBT completers compared with treatment-as-usual patients (F = 6.38, P = 0.01). Short Form-12 mental score (F = 5.00, P = 0.03) was also significantly better in CCBT compared with treatment-as-usual patients at 12 weeks. These outcomes were not maintained at 6 months. The predictors of dropout were baseline depression, biological use, lower IBD Questionnaire scores, and not having steroids.Improvements at 12 weeks after baseline were not maintained at 6 months. Future research should aim to improve adherence rates. Moreover, CCBT may not work for patients with IBD with comorbid depression.
dc.description.statementofresponsibilityAndrew McCombie, Richard Gearry, Jane Andrews, Roger Mulder and Antonina Mikocka-Walus
dc.identifier.citationInflammatory Bowel Diseases, 2016; 22(1):171-181
dc.identifier.doi10.1097/MIB.0000000000000567
dc.identifier.issn1078-0998
dc.identifier.issn1536-4844
dc.identifier.orcidAndrews, J. [0000-0001-7960-2650]
dc.identifier.orcidMikocka-Walus, A. [0000-0003-4864-3956]
dc.identifier.urihttp://hdl.handle.net/2440/104925
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.rightsCopyright © 2015 Crohn ’ s & Colitis Foundation of America, Inc.
dc.source.urihttps://doi.org/10.1097/mib.0000000000000567
dc.subjectHumans
dc.subjectInflammatory Bowel Diseases
dc.subjectPrognosis
dc.subjectTherapy, Computer-Assisted
dc.subjectFollow-Up Studies
dc.subjectDepressive Disorder, Major
dc.subjectQuality of Life
dc.subjectAdult
dc.subjectFemale
dc.subjectMale
dc.subjectCognitive Behavioral Therapy
dc.titleDoes computerized cognitive behavioral therapy help people with inflammatory bowel disease? A randomized controlled trial
dc.typeJournal article
pubs.publication-statusPublished

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