Effect of long-term mobile communication microwave exposure on vascular permeability in mouse brain

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dc.contributor.authorFinnie, J.
dc.contributor.authorBlumbergs, P.
dc.contributor.authorManavis, J.
dc.contributor.authorUtteridge, T.
dc.contributor.authorGebski, V.
dc.contributor.authorDavies, R.
dc.contributor.authorVernon-Roberts, B.
dc.contributor.authorKuchel, T.
dc.date.issued2002
dc.description.abstract<h4>Aims</h4>To study the effect of long-term exposure to global system for mobile communication (GSM) radiofrequency fields on vascular permeability in murine brains.<h4>Methods</h4>Using a purpose-designed exposure system at 900 MHz, mice were given a 60-minute far-field, whole body exposure on each of 5 days per week for 104 weeks at specific absorption rates (SAR) of 0.25, 1.0,2.0 and 4.0 W/kg. Control mice were sham-exposed or permitted free movement in a cage to evaluate any stress-related effects. Albumin immunohistochemistry was used to detect increased vascular permeability and the efficacy of the vascular tracer was confirmed with a positive control group exposed to a clostridial toxin known to increase vascular permeability in the brain.<h4>Results</h4>In all exposed and control groups, albumin extravasation was minimal, often leptomeningeal, and was deemed insignificant as a maximum of three capillaries or venules in a given brain showed leakage from the very many blood vessels present in the three coronal brain sections.<h4>Conclusions</h4>These results suggest that prolonged exposure to mobile telephone-type radiation produces negligible disruption to blood-brain barrier integrity at the light microscope level using endogenous albumin as a vascular tracer.
dc.identifier.citationPathology, 2002; 34(4):344-347
dc.identifier.doi10.1080/003130202760120517
dc.identifier.issn0031-3025
dc.identifier.issn1465-3931
dc.identifier.orcidFinnie, J. [0000-0003-2277-1693]
dc.identifier.orcidManavis, J. [0000-0001-7381-7781] [0000-0003-1268-561X]
dc.identifier.urihttp://hdl.handle.net/2440/5802
dc.language.isoen
dc.publisherCarfax Publishing
dc.source.urihttps://doi.org/10.1080/003130202760120517
dc.subjectAnimals
dc.subjectMice, Inbred C57BL
dc.subjectMice
dc.subjectSerum Albumin
dc.subjectImmunohistochemistry
dc.subjectCapillary Permeability
dc.subjectCerebrovascular Circulation
dc.subjectMicrowaves
dc.subjectFemale
dc.subjectCell Phone
dc.titleEffect of long-term mobile communication microwave exposure on vascular permeability in mouse brain
dc.typeJournal article
pubs.publication-statusPublished

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