Açaí (Euterpe oleraceae Mart.) berry extract exerts neuroprotective effects against β-amyloid exposure in vitro

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dc.contributor.authorWong, D.
dc.contributor.authorMusgrave, I.
dc.contributor.authorHarvey, B.
dc.contributor.authorSmid, S.
dc.date.issued2013
dc.description.abstractThe native South American palm açaí berry (Euterpe oleraceae Mart.) has high polyphenolic and antioxidant levels. This study examined whether açaí berry extract afforded protection against β-amyloid (Aβ)-mediated loss of cell viability and oxidative stress associated with anti-fibrillar effects. PC12 cells were exposed to either Aβ1-42, Aβ25-35 or tert butyl hydroperoxide (t-BHP), alone or in the presence of açaí extract (0.5-50μg/ml). Thioflavin T (ThT) binding assay and transmission electron microscopy were used to determine effects of açaí extract on Aβ1-42 fibril morphology and compared to açaí phenolics gallic acid, cyanidin rutinoside and cyanidin glucoside. Exposure to Aβ1-42, Aβ25-35 or t-BHP decreased PC12 cell viability. Pretreatment with açaí extract significantly improved cell viability following Aβ1-42 exposure, however Aβ25-35 or t-BHP-mediated viability loss was unaltered. Açaí extract inhibited ThT fluorescence and disrupted Aβ1-42 fibril and aggregate morphology. In comparison with other phenolics, açaí was most effective at inhibiting Aβ1-42 aggregation. Inhibition of β-amyloid aggregation may underlie a neuroprotective effect of açaí.
dc.description.statementofresponsibilityDaphne Yiu San Wong, Ian Francis Musgrave, Benjamin Scott Harvey, Scott Darryl Smid
dc.identifier.citationNeuroscience Letters, 2013; 556:221-226
dc.identifier.doi10.1016/j.neulet.2013.10.027
dc.identifier.issn0304-3940
dc.identifier.issn1872-7972
dc.identifier.orcidMusgrave, I. [0000-0003-1016-0588]
dc.identifier.orcidSmid, S. [0000-0003-4192-7219]
dc.identifier.urihttp://hdl.handle.net/2440/81631
dc.language.isoen
dc.publisherElsevier Sci Ireland Ltd
dc.rights© 2013 Elsevier Ireland Ltd.
dc.source.urihttps://doi.org/10.1016/j.neulet.2013.10.027
dc.subjectAçaí
dc.subjectAmyloid-β
dc.subjectCyanidin glucoside
dc.subjectCyanidin rutinoside
dc.subjectGallic acid
dc.subjectOxidative stress
dc.titleAçaí (Euterpe oleraceae Mart.) berry extract exerts neuroprotective effects against β-amyloid exposure in vitro
dc.title.alternativeAcai (Euterpe oleraceae Mart.) berry extract exerts neuroprotective effects against beta-amyloid exposure in vitro
dc.typeJournal article
pubs.publication-statusPublished

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