Altered Insulin-Like Growth Factor binding Proteins

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dc.contributor.assigneeUniversity of Adelaide
dc.contributor.authorForbes, B.
dc.contributor.otherA.P.T. Patent and Trade Mark Attorneys
dc.date.issued2010
dc.descriptionPATENT: B. Forbes (Assignee: University of Adelaide). WO 2004/007543 A1 (PCT/AU2003/000898) filed Jul 11, 2003; published Jan 22, 2004
dc.description.abstractAltered IGFBPs are able to bind IGF but the release is inhibited by resistance to protease cleavage and/or reduced binding to extracellular matrix (ECM). Alterations have been made in IGFBP-2 to the linker domain in particular and two amino acid motifs found to be important for ECM binding. IGF-1 mediated proliferation of cancer cells have been inhibited by the use of these altered IGFBPs.
dc.description.statementofresponsibilityInvented by B. Forbes; assigened to University of Adelaide; A.P.T. Patent and Trade Mark Attorneys agent for inventors.
dc.description.urihttp://www.patentlens.net/patentlens/patent/WO_2004_007543_A1/en/
dc.identifier.patent4559222
dc.identifier.urihttp://hdl.handle.net/2440/74648
dc.language.isoen
dc.subjectWO 2004/007543 A1
dc.titleAltered Insulin-Like Growth Factor binding Proteins
dc.typePatent
pubs.publication-statusPublished

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