ARID proteins come in from the desert
Date
2000
Authors
Kortschak, R.
Tucker, P.
Saint, R.
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Journal article
Citation
Trends in Biochemical Sciences, 2000; 25(6):294-299
Statement of Responsibility
R. Daniel Kortschak, Philip W. Tucker and Robert Saint
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Abstract
Members of the recently discovered ARID (AT-rich interaction domain) family of DNA-binding proteins are found in fungi and invertebrate and vertebrate metazoans. ARID-encoding genes are involved in a variety of biological processes including embryonic development, cell lineage gene regulation and cell cycle control. Although the specific roles of this domain and of ARID-containing proteins in transcriptional regulation are yet to be elucidated, they include both positive and negative transcriptional regulation and a likely involvement in the modification of chromatin structure.
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Copyright © 2000 Elsevier Science Ltd. All rights reserved.