Comparison of stool microbiota compositions, stool alpha1-antitrypsin and calprotectin concentrations, and diarrhoeal morbidity of Indonesian infants fed breast milk or probiotic/prebiotic-supplemented formula

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dc.contributor.authorOswari, H.
dc.contributor.authorPrayitno, L.
dc.contributor.authorDwipoerwantoro, P.
dc.contributor.authorFirmansyah, A.
dc.contributor.authorMakrides, M.
dc.contributor.authorLawley, B.
dc.contributor.authorKuhn-Sherlock, B.
dc.contributor.authorCleghorn, G.
dc.contributor.authorTannock, G.
dc.date.issued2013
dc.description.abstractAIM: The composition of faecal microbiota of babies is known to be influenced by diet. Faecal calprotectin and a1-antitrypsin concentrations may be associated with mucosal permeability and inflammation. We aimed to assess whether there was any difference after consumption of a probiotic/prebiotic formula on faecal microbiota composition, calprotectin and a1-antitrypsin levels, and diarrhoea in comparison with breast milk-fed Indonesian infants. METHODS: One hundred sixty infants, 2 to 6 weeks old, were recruited to the study. They were either breastfed or formula fed (80 per group). Faecal samples were collected at recruitment and 3 months later. Bacterial groups characteristic of the human faecal microbiota were quantified in faeces by quantitative polymerase chain reaction. Calprotectin and a1-antitrypsin concentrations were measured using commercial kits. Details of diarrhoeal morbidity were documented and rated for severity. RESULTS: The compositions of the faecal microbiota of formula-fed compared with breast milk-fed children were similar except that the probiotic strain Bifidobacterium animalis subsp. lactis DR10 was more abundant after 3 months consumption of the formula. Alpha1-antitrypsin levels were higher in breastfed compared with formula-fed infants. The occurrence of diarrhoea did not differ between the groups of babies. CONCLUSION: Feeding Indonesian babies with a probiotic/prebiotic formula did not produce marked differences in the composition of the faecal microbiota in comparison with breast milk. Detrimental effects of formula feeding on biomarkers of mucosal health were not observed.
dc.description.statementofresponsibilityHanifah Oswari, Lamtorogung Prayitno, Pramita G Dwipoerwantoro, Agus Firmansyah, Maria Makrides, Blair Lawley, Barbara Kuhn-Sherlock, Geoffrey Cleghorn and Gerald W. Tannock
dc.identifier.citationJournal of Paediatrics and Child Health, 2013; 49(12):1032-1039
dc.identifier.doi10.1111/jpc.12307
dc.identifier.issn1034-4810
dc.identifier.issn1440-1754
dc.identifier.orcidMakrides, M. [0000-0003-3832-541X]
dc.identifier.urihttp://hdl.handle.net/2440/80851
dc.language.isoen
dc.publisherBlackwell Publishing Asia
dc.rights© 2013 The Authors
dc.source.urihttps://doi.org/10.1111/jpc.12307
dc.subjectIntestinal Mucosa
dc.subjectMilk, Human
dc.subjectFeces
dc.subjectHumans
dc.subjectBifidobacterium
dc.subjectDiarrhea
dc.subjectalpha 1-Antitrypsin
dc.subjectLeukocyte L1 Antigen Complex
dc.subjectCohort Studies
dc.subjectPolymerase Chain Reaction
dc.subjectBreast Feeding
dc.subjectInfant Formula
dc.subjectProbiotics
dc.subjectInfant
dc.subjectInfant, Newborn
dc.subjectIndonesia
dc.subjectFemale
dc.subjectMale
dc.subjectPrebiotics
dc.subjectMicrobiota
dc.subjectBiomarkers
dc.titleComparison of stool microbiota compositions, stool alpha1-antitrypsin and calprotectin concentrations, and diarrhoeal morbidity of Indonesian infants fed breast milk or probiotic/prebiotic-supplemented formula
dc.typeJournal article
pubs.publication-statusPublished

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