Proteomic investigations and biomarker discovery in transient ischaemic attack

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dc.contributor.advisorKoblar, Simon
dc.contributor.advisorHamilton-Bruce, Monica Anne
dc.contributor.advisorLewis, Martin David
dc.contributor.advisorChataway, Timothy K.
dc.contributor.authorDjukic, Michael
dc.contributor.schoolAdelaide Medical Schoolen
dc.date.issued2017
dc.description.abstractBetween 15-26% of ischaemic strokes are preceded by transient ischaemic attack (TIA) making accurate and timely diagnosis of TIA important for stroke prevention. However, TIA diagnoses are highly reliant on subjective history gathering and clinical assessments to differentially diagnose true TIA conditions from mimic presentations. Unfortunately, the subjective nature of TIA diagnosis has created a surprisingly high amount of variability between diagnoses made by physicians and specialist neurologists. Use of biomarker tests could offer an objective quantitative measuring tool that reduces inter-observer variation through the establishment of standardised quantitative measures and improved reproducibility. When used in combination with comprehensive clinical assessments and neurological imaging, biomarkers may offer a useful adjunct to assist a treating clinician to accurately and reliably interpret the clinical finding and confidently diagnose and treat a TIA or mimic condition. This thesis proposes a framework for undertaking an exploration of the human plasma proteome, and performs the very first proteomic pilot study that identifies candidate plasma protein biomarkers associated with TIA, which could also be used to distinguish from mimic presentations.en
dc.description.dissertationThesis (Ph.D.) (Research by Publication) -- University of Adelaide, Adelaide Medical School, 2017.en
dc.identifier.doi10.4225/55/5b20ab1c98bb3
dc.identifier.urihttp://hdl.handle.net/2440/112817
dc.provenanceThis electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exceptions. If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legalsen
dc.subjecttransient ischaemic attacken
dc.subjecthuman plasmaen
dc.subjectproteomicsen
dc.subject2D-DIGEen
dc.subjectMRM-MSen
dc.subjectapolipoproteinen
dc.subjectbiomarkeren
dc.subjectResearch by Publication
dc.titleProteomic investigations and biomarker discovery in transient ischaemic attacken
dc.typeThesesen

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