Inappropriate antidiuretic hormone secretion, abdominal pain and disseminated varicella-zoster virus infection: an unusual triad in a patient 6 months post mini-allogeneic peripheral stem cell transplant for chronic myeloid leukemia

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dc.contributor.authorSzabo, F.
dc.contributor.authorHorvath, N.
dc.contributor.authorSeimon, S.
dc.contributor.authorHughes, T.
dc.date.issued2000
dc.description.abstractSevere abdominal pain followed by inappropriate antidiuretic hormone secretion (SIADH) preceding by several days the skin manifestation of varicella-zoster virus (VZV) infection in an immunocompromised patient is described. This is a rare presentation of a severe infection described previously only once in a chronic myeloid leukemia (CML) patient 5 months post allo-BMT during immunosuppressive treatment with cyclosporin A. This is the first case described in the setting of non-myeloablative preparation with fludarabine and melphalan and followed by donor leukocyte infusion (DLI) 2 and 4 months post allo-BMT. The influence of these factors on development of VZV virus infection is discussed. We also highlight the high incidence and high mortality in VZV infection in immunocompromised patients as well as the frequent atypical presentation.
dc.identifier.citationBone Marrow Transplantation, 2000; 26(2):231-233
dc.identifier.doi10.1038/sj.bmt.1702486
dc.identifier.issn0268-3369
dc.identifier.issn1476-5365
dc.identifier.orcidHughes, T. [0000-0002-0910-3730] [0000-0002-7990-4509]
dc.identifier.urihttp://hdl.handle.net/2440/9324
dc.language.isoen
dc.publisherNature Publishing Group
dc.source.urihttps://doi.org/10.1038/sj.bmt.1702486
dc.subjectHumans
dc.subjectHerpesvirus 3, Human
dc.subjectChickenpox
dc.subjectHerpes Zoster
dc.subjectInappropriate ADH Syndrome
dc.subjectAbdominal Pain
dc.subjectLeukocyte Transfusion
dc.subjectHematopoietic Stem Cell Transplantation
dc.subjectTransplantation, Homologous
dc.subjectImmunocompromised Host
dc.subjectMiddle Aged
dc.subjectMale
dc.subjectLeukemia, Myelogenous, Chronic, BCR-ABL Positive
dc.titleInappropriate antidiuretic hormone secretion, abdominal pain and disseminated varicella-zoster virus infection: an unusual triad in a patient 6 months post mini-allogeneic peripheral stem cell transplant for chronic myeloid leukemia
dc.typeJournal article
pubs.publication-statusPublished

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