Synthesis of functionalized piperidinones
Date
2003
Authors
Humphries, M.
Murphy, J.
Phillips, A.
Abell, A.
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Journal article
Citation
Journal of Organic Chemistry, 2003; 68(6):2432-2436
Statement of Responsibility
Mark E. Humphries, James Murphy, Andrew J. Phillips, and Andrew D. Abell
Conference Name
Abstract
A versatile, stereoselective synthesis of 5-hydroxypiperidinones with substituents at N1, C3, and C6 has been developed. The sequence involves ring-closing metathesis of a diene amide and epoxidation of the resulting alkene, followed by base-mediated elimination, and finally hydrogenation.
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Copyright © 2003 American Chemical Society