Cisapride in the control of symptoms in infants with gastroesophageal reflux: A randomized, double-blind, placebo-controlled trial

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dc.contributor.authorCohen, R.
dc.contributor.authorO'Loughlin, E.
dc.contributor.authorDavidson, G.
dc.contributor.authorMoore, D.
dc.contributor.authorLawrence, D.
dc.date.issued1999
dc.description.abstract<h4>Objective</h4>To evaluate the efficacy of cisapride in the treatment of uncomplicated gastroesophageal reflux in children younger than 36 months of age.<h4>Study design</h4>A total of 95 patients satisfied the entry criteria and were randomly assigned to double-blind treatment with either cisapride (n = 50), 0.2 mg/kg 4 times daily, or placebo (n = 45) for 2 weeks. At the end of the 2-week treatment period, symptom diary and parental evaluation with repeat 24-hour pH study were performed.<h4>Results</h4>Sixty-eight patients completed the trial (38 in the cisapride group and 30 in the placebo group). There were no significant differences in the symptoms of crying, vomiting, or gagging; the overall symptom intensity score; or parental global evaluations. There was a significant difference (P <.03) in the percent time pH <4, the number of reflux episodes lasting more than 5 minutes, and the duration of the longest episode. No significant difference was demonstrated for the number of episodes with pH <4 or the reflux score.<h4>Conclusions</h4>Cisapride was no better than placebo for relief of symptoms in children with uncomplicated gastroesophageal reflux. A beneficial effect was demonstrated in the cisapride group in relation to the measured parameters for esophageal acid exposure time.
dc.description.statementofresponsibilityCohen, Ralph C. ; O’Loughlin, Edward V. ; Davidson, Geoffrey P. ; Moore, D.J. ; Lawrence, Diana M.
dc.identifier.citationJournal of Pediatrics, 1999; 134(3):287-292
dc.identifier.doi10.1016/S0022-3476(99)70451-8
dc.identifier.issn0022-3476
dc.identifier.issn1097-6833
dc.identifier.urihttp://hdl.handle.net/2440/7618
dc.language.isoen
dc.publisherMOSBY-ELSEVIER
dc.source.urihttps://doi.org/10.1016/s0022-3476(99)70451-8
dc.subjectEsophagus
dc.subjectHumans
dc.subjectGastroesophageal Reflux
dc.subjectCisapride
dc.subjectGastrointestinal Agents
dc.subjectPlacebos
dc.subjectTreatment Failure
dc.subjectAdministration, Oral
dc.subjectChi-Square Distribution
dc.subjectStatistics, Nonparametric
dc.subjectDouble-Blind Method
dc.subjectHydrogen-Ion Concentration
dc.subjectInfant
dc.subjectAustralia
dc.subjectFemale
dc.subjectMale
dc.titleCisapride in the control of symptoms in infants with gastroesophageal reflux: A randomized, double-blind, placebo-controlled trial
dc.typeJournal article
pubs.publication-statusPublished

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