Oxygen deteriorates arterial function in type 1 diabetes

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dc.contributor.authorGordin, D.
dc.contributor.authorBernardi, L.
dc.contributor.authorRosengård-Bärlund, M.
dc.contributor.authorMäkinen, V.
dc.contributor.authorSoro-Paavonen, A.
dc.contributor.authorForsblom, C.
dc.contributor.authorSandelin, A.
dc.contributor.authorGroop, P.
dc.date.issued2016
dc.description.abstractAlthough oxygen is commonly used to treat various medical conditions, it has recently been shown to worsen vascular function (arterial stiffness) in healthy volunteers and even more in patients in whom vascular function might already be impaired. The effects of oxygen on arterial function in patients with type 1 diabetes (T1D) are unknown, although such patients display disturbed vascular function already at rest. Therefore, we tested whether short-term oxygen administration may alter the arterial function in patients with T1D.We estimated arterial stiffness by augmentation index (AIx) and the pulse wave velocity equivalent (SI-DVP) in 98 patients with T1D and 49 age- and sex-matched controls at baseline and during hyperoxia by obtaining continuous noninvasive finger pressure waveforms using a recently validated method.AIx and SI-DVP increased in patients (P < 0.05) but not in controls in response to hyperoxia. The increase in AIx (P = 0.05), systolic (P < 0.05), and diastolic (P < 0.05) blood pressure was higher in the patients than in the controls.Short-term oxygen administration deteriorates arterial function in patients with T1D compared to non-diabetic control subjects. Since disturbed arterial function plays a major role in the development of diabetic complications, these findings may be of clinical relevance.
dc.description.statementofresponsibilityDaniel Gordin, Luciano Bernardi, Milla Rosengård-Bärlund, Ville-Petteri Ma, kinen, Aino Soro-Paavonen, Carol Forsblom, Anna Sandelin, Per-Henrik Groop
dc.identifier.citationActa Diabetologica, 2016; 53(3):349-357
dc.identifier.doi10.1007/s00592-015-0775-3
dc.identifier.issn0940-5429
dc.identifier.issn1432-5233
dc.identifier.urihttp://hdl.handle.net/2440/118554
dc.language.isoen
dc.publisherSpringer-Verlag
dc.rights© Springer-Verlag Italia 2015
dc.source.urihttps://doi.org/10.1007/s00592-015-0775-3
dc.subjectAugmentation index; blood pressure; hyperoxia; oxygen; pulse wave velocity; type 1 diabetes
dc.titleOxygen deteriorates arterial function in type 1 diabetes
dc.typeJournal article
pubs.publication-statusPublished

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