Use of high-performance liquid chromatography to study the pharmacokinetics of colistin sulfate in rats following intravenous administration
Date
2003
Authors
Li, J.
Milne, R.
Nation, R.
Turnidge, J.
Smeaton, T.
Coulthard, K.
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Antimicrobial Agents and Chemotherapy, 2003; 47(5):1766-1770
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Abstract
The pharmacokinetics of colistin was investigated using specific high-performance liquid chromatography (HPLC) to measure the concentrations of colistin and colistin A and B in plasma and urine in five rats after administration of an intravenous bolus of 1 mg of colistin sulfate/kg of body weight. There were differences in the pharmacokinetic behaviors of unbound colistin A and B. This is the first report of the use of HPLC to study the pharmacokinetics of colistin and its two major components.
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