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Site-selectively coated, densely-packed microprojection array patches for targeted delivery of vaccines to skin

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dc.contributor.authorChen, X.
dc.contributor.authorCorbett, H.J.
dc.contributor.authorYukiko, S.
dc.contributor.authorRaphael, A.P.
dc.contributor.authorFairmaid, E.J.
dc.contributor.authorProw, T.W.
dc.contributor.authorBrown, L.E.
dc.contributor.authorFernando, G.J.P.
dc.contributor.authorKendall, M.A.F.
dc.date.issued2011
dc.descriptionData source: Supporting information, http://onlinelibrary.wiley.com/doi/10.1002/adfm.201000966/abstract;jsessionid=E1564BD17C07D4F0D2FB80E7ABE67A28.f04t01
dc.description.abstractDensely packed dry-coated microprojections are shown to deliver vaccines to targeted locations within the skin that are rich in immune cells, thus inducing protective immune responses against a lethal virus challenge. Selectively limiting the antigen coating to the tips of the projections, which penetrate the skin, would significantly reduce the amount of vaccine required in immunization. In this paper a simple technique, dip-coating the microprojections, is introduced to meet this goal. By increasing the coating solution viscosity, an otherwise strong capillary action is mitigated and the desired controlled coating length on projections is achieved. Following application to the skin, most of the coated vaccine material is rapidly released from the projections (82.6% in mass within 2 min) to the target locations within the skin strata and a potent immune response is induced when a conventional influenza vaccine (Fluvax) is tested in a mouse model. The utility of this coating approach to a variety of molecules representative of vaccines (e. g., chicken egg ovalbumin (OVA) protein, DNA, and fluorescent dyes) is demonstrated. These collective attributes, together with the simplicity of the approach, position the dip-coating method for practical utility in large vaccination campaigns.
dc.identifier.citationAdvanced Functional Materials, 2011; 21(3):464-473
dc.identifier.doi10.1002/adfm.201000966
dc.identifier.issn1616-301X
dc.identifier.issn1616-3028
dc.identifier.urihttps://hdl.handle.net/11541.2/126394
dc.language.isoen
dc.publisherWiley
dc.relation.fundingNHMRC 456150
dc.relation.fundingNHMRC 569726
dc.relation.fundingARC DP077464
dc.rightsCopyright 2011 WILEY Access Condition Notes: Embargoed until
dc.source.urihttps://doi.org/10.1002/adfm.201000966
dc.subjectdrug delivery
dc.subjectfunctional coatings
dc.subjectbiomedical applications
dc.subjectvaccine delivery
dc.titleSite-selectively coated, densely-packed microprojection array patches for targeted delivery of vaccines to skin
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9916130107601831

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